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- W1032016906 abstract "Publisher Summary This chapter describes the molecular correlates of corticosterone action in hippocampal subregions. The hippocampus is a complex neuroanatomical structure that is implicated in learning, memory, development, and maintenance of cognitive functions and regulation of the hypothalamic–pituitary–adrenal axis. It is thought to transduce the effects of adrenal steroids to the neurons of the paraventricular nucleus that express corticotropin-releasing hormone and arginine-vasopressin, which are secretagogues of proopiomelanocortin. Chronic stress, or a paradigm designed to mimic such a state, for example, chronic administration of corticosterone to adrenalectomized male rats, can cause neuronal cell death in selected subregions of the hippocampus. The chapter discusses the characterization of diagnostic expression profiles for one or more selected hippocampal subregions that are selectively susceptible to glucocorticoid (GC)-induced cell death in this treatment paradigm, at specific time points. This is a suitable approach to contrast the selective vulnerability of particular subregions, and to elucidate the molecular events that accompany susceptibility and increased resistance." @default.
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- W1032016906 date "1994-01-01" @default.
- W1032016906 modified "2023-10-14" @default.
- W1032016906 title "Molecular Correlates of Corticosterone Action in Hippocampal Subregions" @default.
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- W1032016906 doi "https://doi.org/10.1016/b978-0-12-185292-4.50025-5" @default.
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