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• W1032693009 abstract "Background: Renal involvement in systemic lupus erythematosus (SLE) is a common manifestation and a strong predictor of poor outcome. Clinically significant renal involvement ranges from asymptomatic urinary findings to nephritic syndrome and renal failure. Several urinary chemokines and cytokines have been investigated in an attempt to complement and/or find an alternative to renal biopsy. Among these, lipocalin-2 is a promising one; therefore this study aims to assess the role of urinary lipocalin-2 as a biomarker in the diagnosis of lupus nephritis patients. Subjects and Methods: Measurement of urinary lipocalin-2 by ELISA in 44 patients with SLE were divided into two groups; twenty two patients with lupus nephritis (LN) as group (I), and twenty two SLE patients without LN as group (II), in addition to thirty healthy controls of matched age and sex as group (III). Results: Urinary lipocalin-2 levels were significantly higher in patients with lupus nephritis than in the SLE patients without nephritis or the control group. The diagnostic reliability of urinary lipocalin-2 to discriminate SLE patients with nephritis from those without nephritis, it showed a sensitivity of 85% and specificity of 100%, at cut off value 13.2ng/dl, with accuracy 92%. Conclusions: Urinary lipocalin-2 could be used as an early marker for kidney function deterioration in SLE." @default.
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• W1032693009 date "2015-01-01" @default.
• W1032693009 modified "2023-09-26" @default.
• W1032693009 title "Study of Urinary Neutrophil Gelatinase Associated Lipocalin-2(uNGAL) as a Marker in Renal Disease Activity with Systemic Lupus Erythematosis (Lupus Nephritis)" @default.
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