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- W1033040053 abstract "Currently available treatment approaches for Parkinson׳s disease (PD) are limited in terms of variety and efficacy. Piper longum L. (PLL; Piperaceae) is used in traditional medicine in Asia and the Pacific Islands, with demonstrated anti-inflammatory and antioxidant activities in preclinical studies, and alkaloid extracts of PLL have shown protective effects in PD models. The present study investigated the mechanistic basis for the observed protective effects of PLL. Rats treated with PLL-derived alkaloids showed improvement in rotenone-induced motor deficits, while reactive oxygen species (ROS) production was decreased, mitochondrial membrane potential was stabilized, and the opening of the mitochondrial permeability transition pore (mPTP)-which is involved in ROS production-was inhibited. In addition, rotenone-induced apoptosis was abrogated in the presence of these alkaloids, while a pretreatment stimulated autophagy, likely mitigating neuronal injury by the removal of damaged mitochondria. These findings provide novel insight into the neuroprotective function of PLL as well as evidence in favor of its use in PD treatment. This article is part of a Special Issue entitled SI: Neuroprotection." @default.
- W1033040053 created "2016-06-24" @default.
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- W1033040053 date "2016-05-01" @default.
- W1033040053 modified "2023-10-18" @default.
- W1033040053 title "Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury" @default.
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- W1033040053 cites W1625071251 @default.
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- W1033040053 cites W1963907102 @default.
- W1033040053 cites W1965123424 @default.
- W1033040053 cites W1965224599 @default.
- W1033040053 cites W1965337718 @default.
- W1033040053 cites W1965680695 @default.
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- W1033040053 cites W1989026904 @default.
- W1033040053 cites W1989745698 @default.
- W1033040053 cites W1989909634 @default.
- W1033040053 cites W1999268473 @default.
- W1033040053 cites W2003229478 @default.
- W1033040053 cites W2008700509 @default.
- W1033040053 cites W2010023860 @default.
- W1033040053 cites W2014355640 @default.
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- W1033040053 doi "https://doi.org/10.1016/j.brainres.2015.07.029" @default.
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