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- W103348874 abstract "Congenital factor VII (FVII) deficiency is a rare hemorrhagic disorder, and, in affected patients, surgery is likely to cause excessive bleeding. In this article, we report the first case of total hip arthroplasty in a patient with severe congenital FVII deficiency in which recombinant activated factor VII (rFVIIa, NovoSeven) was successfully used to manage bleeds. The patient was a 68-year-old woman with severe congenital FVII deficiency, who suffered from a hemorrhagic arthrosis of her left hip joint. We administered rFVIIa as intermittent bolus infusions both perioperatively and postoperatively; dosing was based on the results of a preoperative rFVIIa challenge test. During surgery and the 3-day postoperative treatment period, we observed normal hemostasis with no excessive bleeding or complications." @default.
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- W103348874 date "2005-04-01" @default.
- W103348874 modified "2023-09-25" @default.
- W103348874 title "Total Hip Arthroplasty in Severe Congenital Factor VII Deficiency" @default.
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- W103348874 doi "https://doi.org/10.1016/j.arth.2004.01.015" @default.
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