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- W1034066093 abstract "Unlike the skin, which is relatively impermeable, mucosal surfaces allow for the intake of oxygen, water, and other nutrients, and the excretion of metabolic by-products. This relatively permeable nature places unique constraints and requirements on the immunocytes, which protect mucosal surfaces, and makes these sites particularly susceptible to penetration by infectious agents. Despite the relative efficiency of the mucosal immune system in preventing infection, the respiratory, gastrointestinal, and vaginal mucosa represent major portals of entry for pathogens (1,2). Locally produced and secreted IgA and cytotoxic T lymphocytes (CTL) within the mucosal tissue and draining lymph nodes protect against microbial infection (1–4). Because the mucosal immune system serves a front line role in protecting us from potential pathogens, there is a great deal of interest in developing strategies for stimulating protective mucosal immune responses. Live viral vaccines, such as the attenuated oral polio vaccine, induce strong mucosal immune responses. However, only a limited number of attenuated vaccines exist. The majority used in clinical practice are derived from recombinant proteins (2). These protein based vaccines tend to induce humoral but not cellular immunity when injected systemically, and mucosal delivery often leads to tolerance." @default.
- W1034066093 created "2016-06-24" @default.
- W1034066093 creator A5087340704 @default.
- W1034066093 date "2002-01-01" @default.
- W1034066093 modified "2023-09-23" @default.
- W1034066093 title "Immunostimulatory DNA Sequence Based Mucosal Vaccines" @default.
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- W1034066093 doi "https://doi.org/10.1007/978-1-59259-305-7_15" @default.
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