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- W103408575 abstract "To study the effects of emodin on proliferation and differentiation of 3T3-L1 preadipocyte and the possible mechanism.Cell proliferation was determined by MTT spectrophotometry, cell differentiation was determined by Oil Red O staining,and fatty acid synthase (FAS) activity was determined by spectrophotometry.Emodin promoted proliferation of 3T3-L1 preadipocyte at low concentration and inhibited the proliferation at high concentration in a dose-related manner. In contrast, it inhibited cell differentiation into adipocyte at low concentration in a dose-related manner. In vitro emodin inhibited the activity of FAS in a dose-related manner.The effects of emodin on 3T3-L1 cell's proliferation and differentiation are dose dependent. Emodin inhibits the activity of FAS. Our results suggest that emodin should have a potential to serve as a fat-reducing drug." @default.
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- W103408575 date "2002-07-01" @default.
- W103408575 modified "2023-09-26" @default.
- W103408575 title "Effect of emodin on proliferation and differentiation of 3T3-L1 preadipocyte and FAS activity." @default.
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