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- W1034134148 abstract "In clonal PC12 cells (differentiated with nerve growth factor), nicotine (100 µmol/1) induces exocytotic release of 3H-noradrenaline, since release (1) depends absolutely on the presence of extracellular calcium and (2) is associated with release of neuropeptide Y. The tricyclic antidepressant desipramine potently inhibits nicotine-induced noradrenaline release. However, desipramine is a much less potent inhibitor when release is elicited by the calcium ionophore A23187 or by potassium-induced depolarization. Desipramine most probably blocks the nicotinic acetylcholine receptor or the receptor-related cation channel." @default.
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- W1034134148 date "1991-01-01" @default.
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- W1034134148 title "Desipramine Inhibits the Nicotine-Induced Exocytosis in Rat Phaeochromocytoma Cells (PC12)" @default.
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- W1034134148 doi "https://doi.org/10.1007/978-3-0348-7457-1_33" @default.
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