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- W1034157517 abstract "Cancer is driven by sequential accumulation of genetic alterations leading to the gain- and loss-of-function of critical cellular proteins. Genes of several families (kinases, phosphatases, ras, gpcrs, etc.) with similar functions, as predicted by similar coding sequences and protein domains, are known to be significantly altered in cancer. Targeted therapy directed against the activity of specific gene products that confer “oncogene addiction” to tumor cells minimizes general toxicity associated with the nonspecific chemotherapy treatments. The success though is restricted to a smaller subset of patients due to development of resistance. One solution to the enduring challenge of drug resistance is rational combinatorial targeted therapy targeting multiple domains across gene families.KeywordsTargeted therapyKinasePhosphataseSmall GTPaseResistance to targeted therapy" @default.
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- W1034157517 date "2013-07-20" @default.
- W1034157517 modified "2023-09-23" @default.
- W1034157517 title "Domain Specific Targeting of Cancer" @default.
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- W1034157517 doi "https://doi.org/10.1007/978-1-4614-8039-6_12" @default.
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