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• W1034264553 abstract "Abstract BACKGROUND Ultrashortwave (USW) therapy may be a new method for treatment of ischemic cerebrovascular diseases. It is necessary to study its treatment time window. OBJECTIVE To observe the effect of USW on reperfusion injury after occlusion of the middle cerebral artery (MCAO) in rats and discuss its acting mechanisms and best occasion. DESIGN Randomized controlled observation, animal experiment. SETTING Laboratory of Department of Rehabilitation Medicine, First Hospital Affiliated to China Medical University. MATERIALS Sixty-six healthy Wistar rats of either gender and of clean grade, aged 18 – 20 weeks, weighing from 250 to 300 g, were provided by the Experimental Animal Center of China Medical University. An USW device (Shanghai Electrical Device Company) with the frequency of 40.68 MHz and the maximum output power of 40 W, and the first channel power controlled at about 11 W was used in this study. Output power was determined by photometry. METHODS Sixty-six rats were randomly divided into 3 groups: Sham-operation group (n = 6): The suture was inserted only 1.0 depth during operation, which did not cause MACO; Model group (n = 12): The USW treatment procedure was performed with the power off on the model rats; USW treatment group (n = 48): The 48 rats were randomly divided into modeling 0, 6, 12 and 18 hours 4 subgroups. USW therapy without heat was used on the head of rats for 10 minutes at each time point. Twelve rats in USW treatment group were decapitated following treatment at each time point, and then their brain tissues were harvested. The rat brain tissues in other groups were harvested by decapitation at 24 hours after modeling. When the rats were awake, the neurologic deficit was scored by Zea-Longa five-point scale (a score of 0 indicated no neurologic deficit, a score of 1 indicated failure to extend left paw fully, a score of 2 indicated circling to the left, and a score of 3 indicated falling to the left, and rats with a score of 4 did not walk spontaneously and has a depressed level of consciousness.) Rats which still survived at 24 hours and was scored 1 and 2 on the neurologic scoring were involved in the analysis. (1) Determination of cerebral water content: Cerebral water contents of healthy and injured hemisphere were determined by wet/dry weighing method. Cerebral water content (100%) = (1 – dry/wet weight) × 100%. (2)Infarction volume: The brain tissue was sliced into 2 mm sections and each section was stained with 20 g/L 2,3,5-triphenyltetrazolium chloride (TTC) by TTC staining technique for 30 minutes in a water bath at 37 °C. Then, the section was fixed in 100 g/L formaldehyde for 10 minutes. The infarction volume was analyzed by using an imaging analyzer. (3) Preparation of light microscopic sample: The rat brain tissue fixed by 100 g/L neutral formaldehyde and stained with TTC, were gradiently dehydrated with alcoholic, embedded with paraffin, sliced and stained by HE, finally, the sections were observed under the light microscope. MAIN OUTCOME MEASURES Cerebral water content, cerebral infarction volume and cerebral histomorphology of rats in each group. RESULTS Sixty-six rats were involved in the final analysis. (1) Cerebral water content: There were no significant differences of cerebral water content in healthy hemisphere among groups (P > 0.05). Cerebral water content of injured hemisphere in the model group and at modeling 0, 6, 12 and 18 hours in the USW treatment group was (81.50±0.74) %, (81.02±0.83) %, (79.78±0.70) %, (79.74±0.84) %, (79.39±1.06) %, respectively, which was significantly higher than that in the sham-operation group [(78.09±0.52) %, P CONCLUSION USW may play a protective effect on cerebral ischemia/reperfusion injury by decreasing brain edema and/or cerebral infarction volume. The treatment action of USW may start at 6 hours after reperfusion, and the best occasion of application may be at 18 hours after reperfusion." @default.
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• W1034264553 date "2007-05-25" @default.
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• W1034264553 title "High frequency electrical field-ultrashort wave therapy for treatment of cerebral ischemia/reperfusion injury in rats*: Histopathological evaluation" @default.
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• W1034264553 doi "https://doi.org/10.1016/s1673-5374(20)30004-9" @default.
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