Matches in SemOpenAlex for { <https://semopenalex.org/work/W1034347263> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1034347263 endingPage "95" @default.
- W1034347263 startingPage "67" @default.
- W1034347263 abstract "Over the past three decades, cryogenic electron microscopy (cryo-EM) and single-particle reconstruction (SPR) techniques have evolved into a powerful toolbox for determining biological macromolecular structures. In its original form, the SPR requires a homogeneous sample, i.e., all the projection images represent identical copies of the macromolecules (Frank, Three-dimensional electron microscopy of macromolecular assemblies: visualization of biological molecules in their native state, Oxford University Press, Oxford, 2006). Recent developments in computational classification methods have made it possible to determine multiple conformations/structures of the macromolecules from cryo-EM data obtained from a single biological sample (Agirrezabala et al., Proc Natl Acad Sci 109:6094–6099, 2012; Fischer et al., Nature 466:329–333, 2010; Scheres, J Struct Biol 180:519–530, 2012). However, the existing classification methods involve different amounts of arbitrary decisions, which may lead to ambiguities of the classification results. In this work, we propose a quantitative way of analyzing the results obtained with iterative classification of cryo-EM data. Based on the logs of iterative particle classification, this analysis can provide quantitative criteria for determining the iteration of convergence and the number of distinguishable conformations/structures in a heterogeneous cryo-EM data set. To show its applicability, we tailored this analysis to the classification results of the program RELION (Scheres, Methods Enzymol 482:295–320, 2010; Scheres, J Mol Biol 415:406–418, 2011) using both benchmark and experimental data sets of ribosomes." @default.
- W1034347263 created "2016-06-24" @default.
- W1034347263 creator A5022258349 @default.
- W1034347263 creator A5042892654 @default.
- W1034347263 creator A5052662209 @default.
- W1034347263 creator A5067483347 @default.
- W1034347263 date "2013-10-29" @default.
- W1034347263 modified "2023-09-26" @default.
- W1034347263 title "Quantitative Analysis in Iterative Classification Schemes for Cryo-EM Application" @default.
- W1034347263 cites W1483313280 @default.
- W1034347263 cites W1486850686 @default.
- W1034347263 cites W1492556495 @default.
- W1034347263 cites W1548811283 @default.
- W1034347263 cites W1677689941 @default.
- W1034347263 cites W1976579441 @default.
- W1034347263 cites W1981124257 @default.
- W1034347263 cites W1986576285 @default.
- W1034347263 cites W2003088542 @default.
- W1034347263 cites W2006158980 @default.
- W1034347263 cites W2011665065 @default.
- W1034347263 cites W2017508876 @default.
- W1034347263 cites W2024858227 @default.
- W1034347263 cites W2053742104 @default.
- W1034347263 cites W2062598925 @default.
- W1034347263 cites W2068654340 @default.
- W1034347263 cites W2075704767 @default.
- W1034347263 cites W2076449818 @default.
- W1034347263 cites W2078726019 @default.
- W1034347263 cites W2093977498 @default.
- W1034347263 cites W2104234755 @default.
- W1034347263 cites W2140092984 @default.
- W1034347263 cites W2142158597 @default.
- W1034347263 doi "https://doi.org/10.1007/978-1-4614-9521-5_4" @default.
- W1034347263 hasPublicationYear "2013" @default.
- W1034347263 type Work @default.
- W1034347263 sameAs 1034347263 @default.
- W1034347263 citedByCount "4" @default.
- W1034347263 countsByYear W10343472632014 @default.
- W1034347263 countsByYear W10343472632015 @default.
- W1034347263 countsByYear W10343472632022 @default.
- W1034347263 crossrefType "book-chapter" @default.
- W1034347263 hasAuthorship W1034347263A5022258349 @default.
- W1034347263 hasAuthorship W1034347263A5042892654 @default.
- W1034347263 hasAuthorship W1034347263A5052662209 @default.
- W1034347263 hasAuthorship W1034347263A5067483347 @default.
- W1034347263 hasConcept C11413529 @default.
- W1034347263 hasConcept C124101348 @default.
- W1034347263 hasConcept C13280743 @default.
- W1034347263 hasConcept C178790620 @default.
- W1034347263 hasConcept C185592680 @default.
- W1034347263 hasConcept C185798385 @default.
- W1034347263 hasConcept C186060115 @default.
- W1034347263 hasConcept C204389451 @default.
- W1034347263 hasConcept C205649164 @default.
- W1034347263 hasConcept C20702342 @default.
- W1034347263 hasConcept C2779345167 @default.
- W1034347263 hasConcept C41008148 @default.
- W1034347263 hasConcept C55493867 @default.
- W1034347263 hasConcept C65293305 @default.
- W1034347263 hasConcept C86803240 @default.
- W1034347263 hasConceptScore W1034347263C11413529 @default.
- W1034347263 hasConceptScore W1034347263C124101348 @default.
- W1034347263 hasConceptScore W1034347263C13280743 @default.
- W1034347263 hasConceptScore W1034347263C178790620 @default.
- W1034347263 hasConceptScore W1034347263C185592680 @default.
- W1034347263 hasConceptScore W1034347263C185798385 @default.
- W1034347263 hasConceptScore W1034347263C186060115 @default.
- W1034347263 hasConceptScore W1034347263C204389451 @default.
- W1034347263 hasConceptScore W1034347263C205649164 @default.
- W1034347263 hasConceptScore W1034347263C20702342 @default.
- W1034347263 hasConceptScore W1034347263C2779345167 @default.
- W1034347263 hasConceptScore W1034347263C41008148 @default.
- W1034347263 hasConceptScore W1034347263C55493867 @default.
- W1034347263 hasConceptScore W1034347263C65293305 @default.
- W1034347263 hasConceptScore W1034347263C86803240 @default.
- W1034347263 hasLocation W10343472631 @default.
- W1034347263 hasOpenAccess W1034347263 @default.
- W1034347263 hasPrimaryLocation W10343472631 @default.
- W1034347263 hasRelatedWork W1038769822 @default.
- W1034347263 hasRelatedWork W1945772050 @default.
- W1034347263 hasRelatedWork W2030088437 @default.
- W1034347263 hasRelatedWork W2037635094 @default.
- W1034347263 hasRelatedWork W2075597866 @default.
- W1034347263 hasRelatedWork W2091096627 @default.
- W1034347263 hasRelatedWork W2789692316 @default.
- W1034347263 hasRelatedWork W2972894997 @default.
- W1034347263 hasRelatedWork W4211241259 @default.
- W1034347263 hasRelatedWork W4250973588 @default.
- W1034347263 isParatext "false" @default.
- W1034347263 isRetracted "false" @default.
- W1034347263 magId "1034347263" @default.
- W1034347263 workType "book-chapter" @default.