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- W103444 abstract "Kynurenine metabolites are derived from the oxidation of tryptophan (Trp) and are involved in many diseases. Previous reports have suggested that some kynurenine metabolites produce superoxide radicals and singlet oxygen molecules under UV illumination. We used electron spin resonance (ESR) spectroscopy to analyze the formation of radicals following ultraviolet-B (UV-B) irradiation of Trp and kynurenine metabolites. As the results, strong phenoxyl radical formation was detected following UV-B irradiation of 3-hydroxy-kynuirenine (3HK), a kynurenine metabolite. Alpha-crystallin, the major lens protein, undergoes many post-translational modifications, including oxidation. Oxidation occurs selectively at methionine, histidine, Trp and lysine residues and associated with the development of age-related cataracts. We examined the effect of these amino acids, as well as tyrosine (which forms tyrosyl radicals in vivo) and aspartic acid (which undergoes racemization following exposure to UV irradiation), on radical formation by 3HK. The combination of Trp and 3HK generated a stronger ESR signal than did 3HK alone. The phenoxyl radical formed by 3HK was strongly induced by UV illumination in the presence of Trp. These results indicated that 3HK could easily produce the phenoxyl radicals via electron-transfer interactions with Trp, which act as a photosensitizer induced UV excitation. In addition, this radical promoted photo-oxidation and may enhance the ability of 3HK to cause disease." @default.
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- W103444 date "2009-03-01" @default.
- W103444 modified "2023-09-24" @default.
- W103444 title "UV-B irradiation-induced electron transfer between 3-hydroxykynurenine and tryptophan" @default.
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