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• W1034457699 abstract "Publisher Summary The archetypal neurotrophic factor, nerve growth factor (NGF), was discovered some 45 years ago for its ability to support neurite outgrowth and survival of sympathetic and neural crest-derived sensory neurons. The recent cloning of additional NGF family members revealed the structures of brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5), collectively known as the neurotrophins. This chapter discusses the in vitro actions of the neurotrophins and ciliary neurotrophic factor (CNTF) as well as recent pharmacological studies of these factors in animal models of nerve trauma and neurodegeneration. Advances in biotechnology have allowed largescale production of recombinant neurotrophic factors, permitting the study of these factors in various animal models of the nervous system disorders. Nerve growth factor (NGF) has distinct survival and neurite outgrowth promoting activities on sympathetic and neural crest-derived sensory neurons of the dorsal root ganglion (DRG). However, sensory neurons derived from the neural placodes do not appear to require NGF for survival or process outgrowth. The observation that NGF displays a limited spectrum of neurotrophic activities within the nervous system prompted the search for additional trophic substances, potentially related to NGF that might subserve trophic functions on neuronal populations not responsive to NGF. The current status of the biological spectra of the four known neurotrophins on cultured embryonic neurons is described and emphasizes the point that many factors have overlapping as well as distinct patterns of activities, fulfilling the notion that multiple factors exists to subserve various trophic functions on the wide array of neurons within the peripheral and the central nervous systems (PNS, CNS). Rapid advances in the field of neurotrophic factors and emerging animal studies have brought hopes for novel therapies for a multitude of neurodegenerative disorders for which there is currently no treatment. Owing in great part to the advances in biotechnology that allow the gram-kilogram scale production of these proteins, the pharmacology of neurotrophic factors can be elucidated." @default.
• W1034457699 created "2016-06-24" @default.
• W1034457699 creator A5089219071 @default.
• W1034457699 date "1993-01-01" @default.
• W1034457699 modified "2023-09-27" @default.
• W1034457699 title "Chapter 2. Pharmacology of Neurotrophic Factors in Models of Neurodegenerative Disease" @default.
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• W1034457699 doi "https://doi.org/10.1016/s0065-7743(08)60872-6" @default.
• W1034457699 hasPublicationYear "1993" @default.
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