Matches in SemOpenAlex for { <https://semopenalex.org/work/W1034701014> ?p ?o ?g. }
- W1034701014 endingPage "125" @default.
- W1034701014 startingPage "117" @default.
- W1034701014 abstract "This chapter discusses studies focusing on antiviral agents. In one series of double-blind placebo-controlled tests, a total of 58 volunteers were treated with 100 mg of amantadine HC1 or placebo twice daily starting 26 hours prior to infection with influenza A2/Rockville/l/65 and treatment was found to significantly diminish the occurrence and severity of the induced disease. In other study, human volunteers were challenged with influenza A2/Moscow/21/65, A2/Leningrad/133/67, or A2/Hong Kong/1/68. Preliminary reports indicated that prophylactic treatment with 100 or 200 mg of amantadine HCl per day provided a good degree of protection against the disease, which was greater than obtained with vaccine. In addition, it was also reported that drug plus antibody or immune γ-globulin provided an additive effect in these challenge studies. Laboratory experiments with mouse-adapted influenza A2/Taiwan/9/64 in mice indicated that either vaccination or amantadine HC1 treatment provided protection from death and that combined treatment showed an additive effect. In another laboratory study, it was demonstrated that although amantadine HC1 treatment offered a high degree of protection against death in mice infected with influenza A2/Japan/305/57, treatment did not significantly reduce lung titers nor reduce the transmission of infection to recipient mice." @default.
- W1034701014 created "2016-06-24" @default.
- W1034701014 creator A5044802417 @default.
- W1034701014 date "1969-01-01" @default.
- W1034701014 modified "2023-09-25" @default.
- W1034701014 title "Chapter 11. Antiviral Agents" @default.
- W1034701014 cites W1535752138 @default.
- W1034701014 cites W1578725384 @default.
- W1034701014 cites W1709629806 @default.
- W1034701014 cites W1964664230 @default.
- W1034701014 cites W1969819656 @default.
- W1034701014 cites W1972647061 @default.
- W1034701014 cites W1974811228 @default.
- W1034701014 cites W1975005949 @default.
- W1034701014 cites W1982075964 @default.
- W1034701014 cites W1985918359 @default.
- W1034701014 cites W1987998935 @default.
- W1034701014 cites W1992242708 @default.
- W1034701014 cites W1993431596 @default.
- W1034701014 cites W1996950853 @default.
- W1034701014 cites W1997833799 @default.
- W1034701014 cites W2001985013 @default.
- W1034701014 cites W2006826708 @default.
- W1034701014 cites W2013488597 @default.
- W1034701014 cites W2014101860 @default.
- W1034701014 cites W2025208844 @default.
- W1034701014 cites W2026898725 @default.
- W1034701014 cites W2028478309 @default.
- W1034701014 cites W2030218993 @default.
- W1034701014 cites W2036243631 @default.
- W1034701014 cites W2040621451 @default.
- W1034701014 cites W2042940710 @default.
- W1034701014 cites W2045985245 @default.
- W1034701014 cites W2046212594 @default.
- W1034701014 cites W2047355812 @default.
- W1034701014 cites W2048634127 @default.
- W1034701014 cites W2050569988 @default.
- W1034701014 cites W2052519854 @default.
- W1034701014 cites W2057634478 @default.
- W1034701014 cites W2069214536 @default.
- W1034701014 cites W2073316707 @default.
- W1034701014 cites W2075809920 @default.
- W1034701014 cites W2079028135 @default.
- W1034701014 cites W2081306728 @default.
- W1034701014 cites W2084968856 @default.
- W1034701014 cites W2085981239 @default.
- W1034701014 cites W2087660488 @default.
- W1034701014 cites W2154732482 @default.
- W1034701014 cites W2166828854 @default.
- W1034701014 cites W2169083289 @default.
- W1034701014 cites W2314526093 @default.
- W1034701014 cites W2318875493 @default.
- W1034701014 cites W2321041466 @default.
- W1034701014 cites W2321912543 @default.
- W1034701014 cites W2324542476 @default.
- W1034701014 cites W2332968308 @default.
- W1034701014 cites W2335206611 @default.
- W1034701014 cites W2417525129 @default.
- W1034701014 cites W2427894075 @default.
- W1034701014 cites W3164239001 @default.
- W1034701014 cites W3165798396 @default.
- W1034701014 cites W4245906067 @default.
- W1034701014 cites W4255040028 @default.
- W1034701014 cites W61758004 @default.
- W1034701014 doi "https://doi.org/10.1016/s0065-7743(08)60651-x" @default.
- W1034701014 hasPublicationYear "1969" @default.
- W1034701014 type Work @default.
- W1034701014 sameAs 1034701014 @default.
- W1034701014 citedByCount "2" @default.
- W1034701014 crossrefType "book-chapter" @default.
- W1034701014 hasAuthorship W1034701014A5044802417 @default.
- W1034701014 hasConcept C126322002 @default.
- W1034701014 hasConcept C142724271 @default.
- W1034701014 hasConcept C159047783 @default.
- W1034701014 hasConcept C159654299 @default.
- W1034701014 hasConcept C203014093 @default.
- W1034701014 hasConcept C204787440 @default.
- W1034701014 hasConcept C22070199 @default.
- W1034701014 hasConcept C27081682 @default.
- W1034701014 hasConcept C2777374534 @default.
- W1034701014 hasConcept C2780035454 @default.
- W1034701014 hasConcept C32611913 @default.
- W1034701014 hasConcept C71924100 @default.
- W1034701014 hasConcept C98274493 @default.
- W1034701014 hasConceptScore W1034701014C126322002 @default.
- W1034701014 hasConceptScore W1034701014C142724271 @default.
- W1034701014 hasConceptScore W1034701014C159047783 @default.
- W1034701014 hasConceptScore W1034701014C159654299 @default.
- W1034701014 hasConceptScore W1034701014C203014093 @default.
- W1034701014 hasConceptScore W1034701014C204787440 @default.
- W1034701014 hasConceptScore W1034701014C22070199 @default.
- W1034701014 hasConceptScore W1034701014C27081682 @default.
- W1034701014 hasConceptScore W1034701014C2777374534 @default.
- W1034701014 hasConceptScore W1034701014C2780035454 @default.
- W1034701014 hasConceptScore W1034701014C32611913 @default.
- W1034701014 hasConceptScore W1034701014C71924100 @default.
- W1034701014 hasConceptScore W1034701014C98274493 @default.
- W1034701014 hasLocation W10347010141 @default.