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- W1034756557 abstract "This chapter focuses on the interaction between the alkali earth cations, particularly calcium, and proteins. An explanation for the interaction between the alkali earth ions and proteins is naturally to be sought for in terms of groups in the protein molecule capable of binding cations and preventing their ionization and the nature of the bonds involved— namely, whether they are covalent or electrostatic. A logical approach to the problem is to seek evidence from the structure of simple compounds of well known composition, whose dissociation is similar to that of the proteins. The problem may also, to a certain degree, be approached in a more empirical fashion by blocking off, through substitution reactions, the reactive functional groups in the protein that could be concerned in the reaction and then testing the product. The most widely known of the biological effects of the incomplete ionization of the alkali earth proteinates is in connection with the regulation of the calcium ion concentration or activity of the blood and the other body fluids. The maintenance of a relatively constant calcium ion concentration in the body fluids is of signal biological importance. The proteins, to a certain degree, take part in this regulation. Calcium ion is important for the coagulation mechanism of the blood for the processes that control the deposition of the mineral matter of the bone and for maintenance of the normal irritability and contractility of heart, skeletal, and smooth muscle." @default.
- W1034756557 created "2016-06-24" @default.
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- W1034756557 date "1944-01-01" @default.
- W1034756557 modified "2023-10-09" @default.
- W1034756557 title "The Interaction between the Alkali Earth Cations, Particularly Calcium, and Proteins" @default.
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- W1034756557 doi "https://doi.org/10.1016/s0065-3233(08)60256-9" @default.
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