Matches in SemOpenAlex for { <https://semopenalex.org/work/W103480297> ?p ?o ?g. }
- W103480297 endingPage "H2523" @default.
- W103480297 startingPage "H2516" @default.
- W103480297 abstract "Increased production of oxygen free radicals is an important mechanism of endothelial dysfunction in diabetes mellitus. Our goal was to test whether adenovirus (Ad)-mediated gene transfer of copper/zinc (CuZn) or manganese superoxide dismutase (Mn SOD) improves relaxation of diabetic vessels. The aortas from 9 alloxan-induced diabetic mellitus (DM) and 16 control rabbits were used. Control and DM rings were transduced ex vivo with Ad vectors encoding Mn SOD (AdMn SOD), CuZn SOD (AdCuZn SOD), beta-galactosidase (Ad(beta)gal), or diluents. In the absence of gene transfer, SOD activity was significantly increased in DM aortas. Transgene expression in DM AdCuZn SOD and DM AdMn SOD-transduced vessels was confirmed by Western blot analysis and by increased SOD activity (DM AdCuZn SOD, 76.2 +/- 9.3; DM AdMn SOD, 65.2 +/- 4.8; P < 0.05 vs. DM Ad(beta)gal; 50.9 +/- 4.4 U/mg protein). Superoxide production was increased in DM Ad(beta)gal-transduced aorta and relaxations to acetylcholine were impaired in these vessels. Gene transfer of CuZn SOD and Mn SOD corrected both of these defects. Thus Ad-mediated gene transfer CuZn and Mn SOD to the diabetic aorta improves endothelium-dependent relaxation." @default.
- W103480297 created "2016-06-24" @default.
- W103480297 creator A5022279955 @default.
- W103480297 creator A5061311035 @default.
- W103480297 creator A5079875502 @default.
- W103480297 creator A5082346434 @default.
- W103480297 date "2001-06-01" @default.
- W103480297 modified "2023-09-30" @default.
- W103480297 title "Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta" @default.
- W103480297 cites W1207588145 @default.
- W103480297 cites W1484535674 @default.
- W103480297 cites W1546753387 @default.
- W103480297 cites W1834350010 @default.
- W103480297 cites W1940436875 @default.
- W103480297 cites W1946263363 @default.
- W103480297 cites W1974573501 @default.
- W103480297 cites W1975974235 @default.
- W103480297 cites W1981618885 @default.
- W103480297 cites W1982065972 @default.
- W103480297 cites W1990800912 @default.
- W103480297 cites W2012365138 @default.
- W103480297 cites W2016649620 @default.
- W103480297 cites W2017554945 @default.
- W103480297 cites W2032550493 @default.
- W103480297 cites W2052931215 @default.
- W103480297 cites W2057545492 @default.
- W103480297 cites W2058137293 @default.
- W103480297 cites W2068852865 @default.
- W103480297 cites W2071881477 @default.
- W103480297 cites W2072902969 @default.
- W103480297 cites W2076018821 @default.
- W103480297 cites W2082953465 @default.
- W103480297 cites W2087737485 @default.
- W103480297 cites W2089736652 @default.
- W103480297 cites W2093518775 @default.
- W103480297 cites W2102933238 @default.
- W103480297 cites W2110342945 @default.
- W103480297 cites W2118313918 @default.
- W103480297 cites W2132933056 @default.
- W103480297 cites W2135879736 @default.
- W103480297 cites W2144100801 @default.
- W103480297 cites W2153876718 @default.
- W103480297 cites W2172077475 @default.
- W103480297 cites W2266556354 @default.
- W103480297 cites W2266860018 @default.
- W103480297 cites W2406163096 @default.
- W103480297 cites W2410551540 @default.
- W103480297 cites W2414970914 @default.
- W103480297 doi "https://doi.org/10.1152/ajpheart.2001.280.6.h2516" @default.
- W103480297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11356606" @default.
- W103480297 hasPublicationYear "2001" @default.
- W103480297 type Work @default.
- W103480297 sameAs 103480297 @default.
- W103480297 citedByCount "56" @default.
- W103480297 countsByYear W1034802972012 @default.
- W103480297 countsByYear W1034802972013 @default.
- W103480297 countsByYear W1034802972014 @default.
- W103480297 countsByYear W1034802972016 @default.
- W103480297 countsByYear W1034802972018 @default.
- W103480297 countsByYear W1034802972021 @default.
- W103480297 countsByYear W1034802972023 @default.
- W103480297 crossrefType "journal-article" @default.
- W103480297 hasAuthorship W103480297A5022279955 @default.
- W103480297 hasAuthorship W103480297A5061311035 @default.
- W103480297 hasAuthorship W103480297A5079875502 @default.
- W103480297 hasAuthorship W103480297A5082346434 @default.
- W103480297 hasConcept C104317684 @default.
- W103480297 hasConcept C126322002 @default.
- W103480297 hasConcept C134018914 @default.
- W103480297 hasConcept C153911025 @default.
- W103480297 hasConcept C185592680 @default.
- W103480297 hasConcept C2775838275 @default.
- W103480297 hasConcept C2776151105 @default.
- W103480297 hasConcept C2776415932 @default.
- W103480297 hasConcept C2778248901 @default.
- W103480297 hasConcept C2779980429 @default.
- W103480297 hasConcept C2780972559 @default.
- W103480297 hasConcept C2781005915 @default.
- W103480297 hasConcept C55493867 @default.
- W103480297 hasConcept C555293320 @default.
- W103480297 hasConcept C71924100 @default.
- W103480297 hasConcept C86803240 @default.
- W103480297 hasConceptScore W103480297C104317684 @default.
- W103480297 hasConceptScore W103480297C126322002 @default.
- W103480297 hasConceptScore W103480297C134018914 @default.
- W103480297 hasConceptScore W103480297C153911025 @default.
- W103480297 hasConceptScore W103480297C185592680 @default.
- W103480297 hasConceptScore W103480297C2775838275 @default.
- W103480297 hasConceptScore W103480297C2776151105 @default.
- W103480297 hasConceptScore W103480297C2776415932 @default.
- W103480297 hasConceptScore W103480297C2778248901 @default.
- W103480297 hasConceptScore W103480297C2779980429 @default.
- W103480297 hasConceptScore W103480297C2780972559 @default.
- W103480297 hasConceptScore W103480297C2781005915 @default.
- W103480297 hasConceptScore W103480297C55493867 @default.
- W103480297 hasConceptScore W103480297C555293320 @default.
- W103480297 hasConceptScore W103480297C71924100 @default.
- W103480297 hasConceptScore W103480297C86803240 @default.