FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1035306681> ?p ?o ?g. }

• W1035306681 endingPage "e0145959" @default.
• W1035306681 startingPage "e0145959" @default.
• W1035306681 abstract "Modeling the effects of anesthetic drugs on brain activity is very helpful in understanding anesthesia mechanisms. The aim of this study was to set up a combined model to relate actual drug levels to EEG dynamics and behavioral states during propofol-induced anesthesia. We proposed a new combined theoretical model based on a pharmacokinetics (PK) model and a neural mass model (NMM), which we termed PK-NMM--with the aim of simulating electroencephalogram (EEG) activity during propofol-induced general anesthesia. The PK model was used to derive propofol effect-site drug concentrations (C(eff)) based on the actual drug infusion regimen. The NMM model took C(eff) as the control parameter to produce simulated EEG-like (sEEG) data. For comparison, we used real prefrontal EEG (rEEG) data of nine volunteers undergoing propofol anesthesia from a previous experiment. To see how well the sEEG could describe the dynamic changes of neural activity during anesthesia, the rEEG data and the sEEG data were compared with respect to: power-frequency plots; nonlinear exponent (permutation entropy (PE)); and bispectral SynchFastSlow (SFS) parameters. We found that the PK-NMM model was able to reproduce anesthesia EEG-like signals based on the estimated drug concentration and patients' condition. The frequency spectrum indicated that the frequency power peak of the sEEG moved towards the low frequency band as anesthesia deepened. Different anesthetic states could be differentiated by the PE index. The correlation coefficient of PE was 0.80 ± 0.13 (mean ± standard deviation) between rEEG and sEEG for all subjects. Additionally, SFS could track the depth of anesthesia and the SFS of rEEG and sEEG were highly correlated with a correlation coefficient of 0.77 ± 0.13. The PK-NMM model could simulate EEG activity and might be a useful tool for understanding the action of propofol on brain activity." @default.
• W1035306681 created "2016-06-24" @default.
• W1035306681 creator A5017085109 @default.
• W1035306681 creator A5030180983 @default.
• W1035306681 creator A5043497497 @default.
• W1035306681 creator A5043856133 @default.
• W1035306681 creator A5048378834 @default.
• W1035306681 creator A5058591723 @default.
• W1035306681 date "2015-12-31" @default.
• W1035306681 modified "2023-09-25" @default.
• W1035306681 title "A Pharmacokinetics-Neural Mass Model (PK-NMM) for the Simulation of EEG Activity during Propofol Anesthesia" @default.
• W1035306681 cites W1122120211 @default.
• W1035306681 cites W1525310058 @default.
• W1035306681 cites W1631538830 @default.
• W1035306681 cites W1976936145 @default.
• W1035306681 cites W1977518154 @default.
• W1035306681 cites W1979264461 @default.
• W1035306681 cites W1979610882 @default.
• W1035306681 cites W1985983039 @default.
• W1035306681 cites W1988148915 @default.
• W1035306681 cites W1988881714 @default.
• W1035306681 cites W1990627553 @default.
• W1035306681 cites W1990752984 @default.
• W1035306681 cites W2002996884 @default.
• W1035306681 cites W2009587231 @default.
• W1035306681 cites W2014683958 @default.
• W1035306681 cites W2015304937 @default.
• W1035306681 cites W2015379854 @default.
• W1035306681 cites W2017091714 @default.
• W1035306681 cites W2020962399 @default.
• W1035306681 cites W2021762465 @default.
• W1035306681 cites W2024177541 @default.
• W1035306681 cites W2037627150 @default.
• W1035306681 cites W2038141274 @default.
• W1035306681 cites W2042413907 @default.
• W1035306681 cites W2043441636 @default.
• W1035306681 cites W2044670283 @default.
• W1035306681 cites W2050716857 @default.
• W1035306681 cites W2051428723 @default.
• W1035306681 cites W2059366852 @default.
• W1035306681 cites W2060201297 @default.
• W1035306681 cites W2061319887 @default.
• W1035306681 cites W2062847304 @default.
• W1035306681 cites W2066305892 @default.
• W1035306681 cites W2077511565 @default.
• W1035306681 cites W2082292958 @default.
• W1035306681 cites W2084995186 @default.
• W1035306681 cites W2089299080 @default.
• W1035306681 cites W2090482728 @default.
• W1035306681 cites W2092247954 @default.
• W1035306681 cites W2093214387 @default.
• W1035306681 cites W2093935776 @default.
• W1035306681 cites W2096209718 @default.
• W1035306681 cites W2099878046 @default.
• W1035306681 cites W2102599105 @default.
• W1035306681 cites W2103288639 @default.
• W1035306681 cites W2105148858 @default.
• W1035306681 cites W2105336635 @default.
• W1035306681 cites W2111902267 @default.
• W1035306681 cites W2115473091 @default.
• W1035306681 cites W2117469172 @default.
• W1035306681 cites W2121409298 @default.
• W1035306681 cites W2122171313 @default.
• W1035306681 cites W2123261069 @default.
• W1035306681 cites W2137778858 @default.
• W1035306681 cites W2150456903 @default.
• W1035306681 cites W2153204292 @default.
• W1035306681 cites W2153230907 @default.
• W1035306681 cites W2160419313 @default.
• W1035306681 cites W2167356357 @default.
• W1035306681 cites W2168811991 @default.
• W1035306681 cites W2327295093 @default.
• W1035306681 cites W2400743000 @default.
• W1035306681 cites W2410297655 @default.
• W1035306681 cites W4250543537 @default.
• W1035306681 doi "https://doi.org/10.1371/journal.pone.0145959" @default.
• W1035306681 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4697853" @default.
• W1035306681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26720495" @default.
• W1035306681 hasPublicationYear "2015" @default.
• W1035306681 type Work @default.
• W1035306681 sameAs 1035306681 @default.
• W1035306681 citedByCount "5" @default.
• W1035306681 countsByYear W10353066812017 @default.
• W1035306681 countsByYear W10353066812020 @default.
• W1035306681 countsByYear W10353066812021 @default.
• W1035306681 countsByYear W10353066812023 @default.
• W1035306681 crossrefType "journal-article" @default.
• W1035306681 hasAuthorship W1035306681A5017085109 @default.
• W1035306681 hasAuthorship W1035306681A5030180983 @default.
• W1035306681 hasAuthorship W1035306681A5043497497 @default.
• W1035306681 hasAuthorship W1035306681A5043856133 @default.
• W1035306681 hasAuthorship W1035306681A5048378834 @default.
• W1035306681 hasAuthorship W1035306681A5058591723 @default.
• W1035306681 hasBestOaLocation W10353066811 @default.
• W1035306681 hasConcept C112705442 @default.
• W1035306681 hasConcept C118552586 @default.
• W1035306681 hasConcept C126322002 @default.
• W1035306681 hasConcept C2776277131 @default.

• next