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- W1036169302 abstract "The development of viral cultures in chicken embryos and mice by Koprowski and Cox in the 1940s and subsequent refinements in viral isolation and molecular biology permitted further description of Colorado tick fever virus (CTFV). Much is now known about its ecological niche and life cycle in vertebrate and invertebrate hosts as well as the epidemiology, pathogenesis, and clinical course of infection in humans. The current taxonomy recognizes three distinct species: (i) the type species, Banna virus (BAV); (ii) Kadipiro virus; and (iii) Liao Ning virus. The pathogenic potential of these viruses in humans remains to be determined, although associations of BAV infection with febrile illnesses and encephalitis are convincing. Seadornaviruses are serologically distinct from CTFV and Eyach virus (EYAV), have a lower G+C content than coltiviruses, and show genetic distances in the RNA-dependent RNA polymerase of more than 90% compared to coltiviruses. The genome of all members of the Reoviridae consists of segmented double-stranded RNA (dsRNA). Electron microscopic (EM) studies of cultured cells following infection reveal viral particles in association with granular matrices within the cytoplasm. The name Orbivirus derives from the appearance of virus particles as large, doughnut-shaped capsomeres by negative-contrast EM. Though the most-studied orbiviruses are agents of veterinary import, a number of serogroups within the genus cause human disease. They are predominantly transmitted by arthropod vectors." @default.
- W1036169302 created "2016-06-24" @default.
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- W1036169302 date "2009-01-01" @default.
- W1036169302 modified "2023-09-26" @default.
- W1036169302 title "Colorado Tick Fever Virus and Other Arthropod-Borne Reoviridae" @default.
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- W1036169302 doi "https://doi.org/10.1128/9781555815981.ch34" @default.
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