Matches in SemOpenAlex for { <https://semopenalex.org/work/W1036194> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1036194 endingPage "354" @default.
- W1036194 startingPage "349" @default.
- W1036194 abstract "BACKGROUND: Sudden, severe airway injury has been associated with an acute, and at times persisting, airway hyper-responsiveness with clinical features of asthma, termed reactive airways dysfunction syndrome (RADS). An attempt was made to develop a rat model of RADS by exposing inbred Fischer rats to inhaled 8 N acetic acid for 2 mins (13 N inhalation was lethal). METHODS: Lung resistance (R L ) and lung elastance (E L ) were measured in 14 eight- to 10-week old male rats. Baseline responsiveness to methacholine was quantified by calculating the dose required for doubling of RL. The next day, the study group (n=11) was exposed to aerosolized acetic acid. Control animals (n=3) were similarly exposed to buffered saline solution. RESULTS: Acetic acid exposure resulted in a significant (P <0.02) increase in RL (by 80%) and EL (by 67%), lasting less than 10 mins postexposure, but no significant change in methacholine responsiveness at one day and seven days postexposure. CONCLUSIONS: Failure to induce persistent airway hyper-responsiveness may relate to the choice of animal, choice of irritant, or insufficient level or duration of exposure, or may reflect a lack of individual predisposing cofactors such as smoking or underlying asthmatic predisposition." @default.
- W1036194 created "2016-06-24" @default.
- W1036194 creator A5028993831 @default.
- W1036194 creator A5036017418 @default.
- W1036194 creator A5039920907 @default.
- W1036194 creator A5040264242 @default.
- W1036194 creator A5045015803 @default.
- W1036194 creator A5056228673 @default.
- W1036194 creator A5086976253 @default.
- W1036194 date "1998-01-01" @default.
- W1036194 modified "2023-09-27" @default.
- W1036194 title "Effect of High Dose Inhaled Acetic Acid on Airway Responsiveness in Fischer Rats" @default.
- W1036194 cites W1896541920 @default.
- W1036194 cites W1983404256 @default.
- W1036194 cites W1987547622 @default.
- W1036194 cites W1992230297 @default.
- W1036194 cites W2018684496 @default.
- W1036194 cites W2023325531 @default.
- W1036194 cites W2033560050 @default.
- W1036194 cites W2040058625 @default.
- W1036194 cites W2049135121 @default.
- W1036194 cites W2095054951 @default.
- W1036194 cites W2098132937 @default.
- W1036194 cites W2230968555 @default.
- W1036194 cites W2037142666 @default.
- W1036194 doi "https://doi.org/10.1155/1998/157193" @default.
- W1036194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9832602" @default.
- W1036194 hasPublicationYear "1998" @default.
- W1036194 type Work @default.
- W1036194 sameAs 1036194 @default.
- W1036194 citedByCount "2" @default.
- W1036194 crossrefType "journal-article" @default.
- W1036194 hasAuthorship W1036194A5028993831 @default.
- W1036194 hasAuthorship W1036194A5036017418 @default.
- W1036194 hasAuthorship W1036194A5039920907 @default.
- W1036194 hasAuthorship W1036194A5040264242 @default.
- W1036194 hasAuthorship W1036194A5045015803 @default.
- W1036194 hasAuthorship W1036194A5056228673 @default.
- W1036194 hasAuthorship W1036194A5086976253 @default.
- W1036194 hasConcept C105922876 @default.
- W1036194 hasConcept C126322002 @default.
- W1036194 hasConcept C185592680 @default.
- W1036194 hasConcept C2776042228 @default.
- W1036194 hasConcept C2776178081 @default.
- W1036194 hasConcept C2776673659 @default.
- W1036194 hasConcept C2776954882 @default.
- W1036194 hasConcept C2777397205 @default.
- W1036194 hasConcept C2777714996 @default.
- W1036194 hasConcept C2781260171 @default.
- W1036194 hasConcept C33362165 @default.
- W1036194 hasConcept C42219234 @default.
- W1036194 hasConcept C55493867 @default.
- W1036194 hasConcept C71924100 @default.
- W1036194 hasConcept C82085835 @default.
- W1036194 hasConceptScore W1036194C105922876 @default.
- W1036194 hasConceptScore W1036194C126322002 @default.
- W1036194 hasConceptScore W1036194C185592680 @default.
- W1036194 hasConceptScore W1036194C2776042228 @default.
- W1036194 hasConceptScore W1036194C2776178081 @default.
- W1036194 hasConceptScore W1036194C2776673659 @default.
- W1036194 hasConceptScore W1036194C2776954882 @default.
- W1036194 hasConceptScore W1036194C2777397205 @default.
- W1036194 hasConceptScore W1036194C2777714996 @default.
- W1036194 hasConceptScore W1036194C2781260171 @default.
- W1036194 hasConceptScore W1036194C33362165 @default.
- W1036194 hasConceptScore W1036194C42219234 @default.
- W1036194 hasConceptScore W1036194C55493867 @default.
- W1036194 hasConceptScore W1036194C71924100 @default.
- W1036194 hasConceptScore W1036194C82085835 @default.
- W1036194 hasIssue "5" @default.
- W1036194 hasLocation W10361941 @default.
- W1036194 hasLocation W10361942 @default.
- W1036194 hasOpenAccess W1036194 @default.
- W1036194 hasPrimaryLocation W10361941 @default.
- W1036194 hasRelatedWork W1978315647 @default.
- W1036194 hasRelatedWork W2031196312 @default.
- W1036194 hasRelatedWork W2040131886 @default.
- W1036194 hasRelatedWork W2083331353 @default.
- W1036194 hasRelatedWork W2085124823 @default.
- W1036194 hasRelatedWork W2088814945 @default.
- W1036194 hasRelatedWork W2398868860 @default.
- W1036194 hasRelatedWork W2412313190 @default.
- W1036194 hasRelatedWork W2414095837 @default.
- W1036194 hasRelatedWork W2417134062 @default.
- W1036194 hasVolume "5" @default.
- W1036194 isParatext "false" @default.
- W1036194 isRetracted "false" @default.
- W1036194 magId "1036194" @default.
- W1036194 workType "article" @default.