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• W1036222471 abstract "Publisher Summary This chapter deals with the IgG-binding FcRs (FcγR) and summarizes the structural features of their membrane-bound and soluble forms, the factors influencing receptor expression, and the possible mechanisms of receptor release. It discusses the importance of various forms of FcγRs in the regulation of humoral responses and the significance of FcγRs in antitumor effector functions. The interaction of FcRs with the immunoglobulin molecules provides a link between specific antigen recognition and effector cells. These receptors play important roles in the defense against infection. The FcRs of B lymphocytes are involved in the regulation of the antibody production. Their release from activated B cells is the consequence of proteolytic cleavage or of alternative splicing. The soluble “truncated” receptor molecules maintain the immunoglobulin-binding domains and regulate the humoral immune response. They inhibit immunoglobulin production in an isotype-specific manner. As components of a regulatory circuit, immunoglobulin-binding factors serve immune surveillance. Due to their participation in effector and regulatory functions, both the membrane-bound and the soluble FcRs are important elements of immune defense. Expressed on the tumors cells, however, these molecules may behave as “traitors” and counteract the activities of the immune system: thus, they can be deleterious to the host response and facilitate the escape of the malignant cells. Evidence suggests that similar FcR-mediated “self-defense” mechanisms exist in parasites and virus-infected cells that can bind the Fc portion of IgG. FcRs or FcR-like molecules on tumor and virus-infected cells, and on bacteria may be used as efficient “survival kits” exploiting the Fc-binding capacity of these molecules." @default.
• W1036222471 created "2016-06-24" @default.
• W1036222471 creator A5068945429 @default.
• W1036222471 creator A5069696610 @default.
• W1036222471 date "1994-01-01" @default.
• W1036222471 modified "2023-09-25" @default.
• W1036222471 title "Fcγ Receptors in Malignancies: Friends or Enemies?" @default.
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