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- W103625774 endingPage "170" @default.
- W103625774 startingPage "117" @default.
- W103625774 abstract "The endoplasmic reticulum is an organelle discovered using the electron microscope (EM) and subsequently found to be present in nearly all cells of higher plants and animals (Claude, 1970; Palade, 1955b, 1956; Palade and Porter, 1954; Porter, 1953; Porter et al., 1945; Porter and Palade, 1957). Ever since 1945, when Porter and co-workers first noticed this organelle, there has been a growing interest concerning the elucidation of the role of the endoplasmic reticulum in cellular processes, such as drug metabolism and control of protein synthesis. Eukaryotic cells specialized for the secretion of proteins contain a large fraction of their ribosomes bound to membranes of the endoplasmic reticulum (Birbeck and Mercer, 1961; Palade, 1956). Secretory polypeptides synthesized by bound ribosomes are vectorially transferred to the lumen of endoplasmic reticulum cisternae as a first step in the process leading to their extracellular discharge (Redman et al., 1966; Redman and Sabatini, 1966)." @default.
- W103625774 created "2016-06-24" @default.
- W103625774 creator A5015390792 @default.
- W103625774 creator A5029700438 @default.
- W103625774 date "1980-01-01" @default.
- W103625774 modified "2023-10-14" @default.
- W103625774 title "Aspects of the Role of the Endoplasmic Reticulum in Protein Synthesis" @default.
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