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• W1036278258 abstract "Publisher Summary This chapter discusses some major new approaches to anti-inflammatory therapy as they relate to pulmonary diseases. National Institutes of Health states that asthma should be treated foremost as an inflammatory disease. Evidence that supports a major role for an inflammatory component in pulmonary diseases, such as asthma, forms the positive clinical effects of steroid therapy. Development of novel entities that impact on the inflammation associated with pulmonary disease could constitute major therapeutic advancements. Novel approaches to anti-inflammatory therapy target the function of T-lymphocytes, mast cells, macrophages, neutrophils, and eosinophils by blocking cell adhesion, migration, and activation. Other new agents inhibit the production or effect of inflammatory mediators, the release of toxic oxygen metabolites and proteins, or inhibit degradative enzymes that some of these cells release. Before leukocytes can transit from the blood to pulmonary tissue, they must first adhere to the vascular endothelium. Close cell-to-cell interactions are critically important in this aspect of the inflammatory process. These intercellular communications are mediated by specific cell-surface glycoproteins, termed adhesion molecules, which are up-regulated in response to agents, such as cytokines and leukotrienes. Cytokines are intercellular regulatory proteins that differ from classical hormones. In that, they are usually made by more than one cell that have a wide range of biologic effects and generally act over short distances. It is possible that overproduction of specific cytokines contributes to the pathogenesis of pulmonary inflammatory diseases. However, it is not possible to predict that specific approaches can yield useful drugs." @default.
• W1036278258 created "2016-06-24" @default.
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• W1036278258 date "1993-01-01" @default.
• W1036278258 modified "2023-10-16" @default.
• W1036278258 title "Chapter 12. Novel Approaches to Anti-Inflammatory Agents as Therapeutics for Pulmonary Disease" @default.
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• W1036278258 doi "https://doi.org/10.1016/s0065-7743(08)60882-9" @default.
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