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- W1036302947 abstract "This chapter presents the experimental results of studies carried out to test purification of somatostatin receptors. The neuropeptide somatostatin (SRIF) is expressed in the central nervous system, and in endocrine and exocrine organs. In the brain, SRIF is a neurotransmitter that regulates neuronal activity and the release of other transmitters, and it may be involved in the generation of centrally mediated behaviors such as movement and cognition. SRIF released from neurons in the hypothalamus acts as a neurohormone in the pituitary and is the major physiological regulator of growth hormone secretion. A procedure to purify brain SRIF receptors to near homogeneity through the use of mild detergents and a SRIF affinity column is developed. The yield of purified receptor is generally low as the affinity column only binds receptors with high affinity for SRIF. This indicates that only SRIF receptors coupled with G proteins bind to the affinity column. Most receptors are uncoupled from the G proteins either because of the solubilization procedure or for other unknown reasons." @default.
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- W1036302947 date "1991-01-01" @default.
- W1036302947 modified "2023-09-27" @default.
- W1036302947 title "Purification of Somatostatin Receptors" @default.
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- W1036302947 doi "https://doi.org/10.1016/b978-0-12-185259-7.50019-3" @default.
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