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- W103630631 abstract "Iron-overload cardiomyopathy is responsible for many deaths in thalassemia patients. Although L-type calcium channel (LTCC) was proposed as a portal for iron entry and deposit in the heart, its role in the heart of thalassemia subject has never been investigated. Growing evidence demonstrated that reexpression of T-type calcium channel (TTCC) was found in diseased myocardium of adult hearts. However, its existence and role for iron entry in thalassemic hearts is unknown. We tested the hypothesis that both LTCC and TTCC are the main portals for iron entry in thalassemic hearts. Methods: Hearts from heterozygous β-globin knockout thalassemic (HT) mice and wild-type (WT) mice (n=8/group) were used for cultured ventricular cardiomyocytes. Various iron (Fe2+) concentrations (10–160 mg/ml) and pharmacological interventions with transferin receptor (TfR) blocker and divalent metal transporter inhibitor (ebselen), LTCC blocker (verapamil), TTCC blocker (efonidipine), and iron chelator desferoxamine (DFO) were use..." @default.
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- W103630631 date "2010-11-23" @default.
- W103630631 modified "2023-09-27" @default.
- W103630631 title "Abstract 11087: T-type Calcium Channel is a Main Portal for Iron Entry in Thalassemic Heart" @default.
- W103630631 hasPublicationYear "2010" @default.
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