FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1036309396> ?p ?o ?g. }

• W1036309396 abstract "In industrialized nations, cerebral ischemia manifesting as a stroke or TIA is one of the most frequent causes of death and the most important reason for long-term disability and the overall associated overall costs for society. Most patients tend to survive ischemic events and, frequently, a virtually full recovery is possible. Because cerebral ischemia is a manifestation of arteriosclerotic vascular lesions, it is important for secondary prevention after such an event to determine the lethality risk as well as make a targeted risk assessment of other expressions of arteriosclerosis. This dissertation investigated the prognostic value of new cardiovascular biomarkers (NTproBNP, proANP, H-FABP, GDF-15 and hsTropT) in predicting the occurrence of all-cause mortality or of a major cardiovascular event (MCE), a combined vascular endpoint that includes acute coronary syndrome, stroke and cardiovascular death. To this aim, 281 patients with cerebral ischemia who presented at the Göttingen University Hospital were studied for one year after the initial event. The data were gathered and statistically analyzed, demonstrating in the univariate Cox regression analysis that GDF-15 (P=0.009), H-FABP (P=0,023) and hsTropT (P=0.001) were significant predictors for MCE. hsTropT (p<0.001), GDF-15 (p=0.007) and NTproBNP (p=0.050) reached a significance level for predicting all-cause mortality. The multivariate regression analysis showed that hsTropT was the only marker with prognostic relevance both for the occurrence of a cardiovascular event as well as for death of the patient. As a result, the predictive power of the protein proved to be superior to established clinical methods for predicting risk, such as the Essen Stroke Risk Score (ESRS) and the Stroke Prognostic Instrument 2 (SPI-2). When these two risk scores were included in the multivariate analysis, it was possible to prove that hsTropT is independent from other influencing factors linked to pathological processes in the cardiovascular system. Nevertheless, the data obtained here should be validated on a larger cohort before these biomarkers can be integrated safely and expediently in routine clinical diagnostics. In particular, this refers to the problem of establishing a limit value that can be used to classify patients into high- and low-risk groups. Any improvement in risk prediction secondary to cerebral ischemia would ultimately benefit patients in the form of a targeted, risk-adapted secondary prevention and improve the long-term prognosis of this disease." @default.
• W1036309396 created "2016-06-24" @default.
• W1036309396 creator A5086166934 @default.
• W1036309396 date "2022-02-20" @default.
• W1036309396 modified "2023-09-30" @default.
• W1036309396 title "Wertigkeit neuer kardiovaskulärer Biomarker zur Prädiktion kardiovaskulärer Ereignisse und der Mortalität bei Patienten mit akuter zerebraler Ischämie" @default.
• W1036309396 cites W146939440 @default.
• W1036309396 cites W1502959700 @default.
• W1036309396 cites W1546258268 @default.
• W1036309396 cites W1585974793 @default.
• W1036309396 cites W1912840638 @default.
• W1036309396 cites W1964421861 @default.
• W1036309396 cites W1964785725 @default.
• W1036309396 cites W1964933452 @default.
• W1036309396 cites W1966329493 @default.
• W1036309396 cites W1966413587 @default.
• W1036309396 cites W1966564237 @default.
• W1036309396 cites W1969390338 @default.
• W1036309396 cites W1969661146 @default.
• W1036309396 cites W1970405416 @default.
• W1036309396 cites W1970516435 @default.
• W1036309396 cites W1972838566 @default.
• W1036309396 cites W1979383399 @default.
• W1036309396 cites W1982074032 @default.
• W1036309396 cites W1988127787 @default.
• W1036309396 cites W1988613997 @default.
• W1036309396 cites W1988816170 @default.
• W1036309396 cites W1989725665 @default.
• W1036309396 cites W1998847172 @default.
• W1036309396 cites W2001009565 @default.
• W1036309396 cites W2001471462 @default.
• W1036309396 cites W2001648888 @default.
• W1036309396 cites W2004287287 @default.
• W1036309396 cites W2007013069 @default.
• W1036309396 cites W2007937185 @default.
• W1036309396 cites W2008050591 @default.
• W1036309396 cites W2008497553 @default.
• W1036309396 cites W2011456940 @default.
• W1036309396 cites W2012578790 @default.
• W1036309396 cites W2013013438 @default.
• W1036309396 cites W2015266979 @default.
• W1036309396 cites W2015911108 @default.
• W1036309396 cites W2016114416 @default.
• W1036309396 cites W2019182813 @default.
• W1036309396 cites W2019358941 @default.
• W1036309396 cites W2019762024 @default.
• W1036309396 cites W2023220528 @default.
• W1036309396 cites W2023478601 @default.
• W1036309396 cites W2024352468 @default.
• W1036309396 cites W2024720175 @default.
• W1036309396 cites W2024828754 @default.
• W1036309396 cites W2025378180 @default.
• W1036309396 cites W2025576182 @default.
• W1036309396 cites W2025969523 @default.
• W1036309396 cites W2026897702 @default.
• W1036309396 cites W2026974388 @default.
• W1036309396 cites W2027123157 @default.
• W1036309396 cites W2027314542 @default.
• W1036309396 cites W2027349677 @default.
• W1036309396 cites W2027538725 @default.
• W1036309396 cites W2027950441 @default.
• W1036309396 cites W2030204325 @default.
• W1036309396 cites W2033660191 @default.
• W1036309396 cites W2036827822 @default.
• W1036309396 cites W2038313195 @default.
• W1036309396 cites W2038722300 @default.
• W1036309396 cites W2042359907 @default.
• W1036309396 cites W2045576718 @default.
• W1036309396 cites W2046929151 @default.
• W1036309396 cites W2049696083 @default.
• W1036309396 cites W2051861388 @default.
• W1036309396 cites W2053230173 @default.
• W1036309396 cites W2053565388 @default.
• W1036309396 cites W2053611632 @default.
• W1036309396 cites W2054455178 @default.
• W1036309396 cites W2054770599 @default.
• W1036309396 cites W2057805796 @default.
• W1036309396 cites W2058302382 @default.
• W1036309396 cites W2058493401 @default.
• W1036309396 cites W2070692648 @default.
• W1036309396 cites W2071008229 @default.
• W1036309396 cites W2071604146 @default.
• W1036309396 cites W2073447943 @default.
• W1036309396 cites W2073849191 @default.
• W1036309396 cites W2075325032 @default.
• W1036309396 cites W2077448872 @default.
• W1036309396 cites W2078368507 @default.
• W1036309396 cites W2080366036 @default.
• W1036309396 cites W2080504768 @default.
• W1036309396 cites W2081273196 @default.
• W1036309396 cites W2082903312 @default.
• W1036309396 cites W2088794031 @default.
• W1036309396 cites W2090317384 @default.
• W1036309396 cites W2094843360 @default.
• W1036309396 cites W2096264103 @default.
• W1036309396 cites W2096600360 @default.
• W1036309396 cites W2097811804 @default.
• W1036309396 cites W2099395511 @default.
• W1036309396 cites W2099961758 @default.
• W1036309396 cites W2106343349 @default.

• next