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- W103631041 endingPage "275" @default.
- W103631041 startingPage "259" @default.
- W103631041 abstract "The CNS has an especially rich capacity to synthesise NO. By virtue of its high rate of diffusion in both lipid and aqueous environments, a single source of NO is likely to influence neural function over a large tissue volume, perhaps equivalent to one containing as many as 1–2 million synapses (Wood and Garthwaite 1994). This large sphere of influence, enclosing a large number of heterogeneous targets (dendrites, axons, presynaptic nerve terminals, glial cells, blood vessels), indicates that the principles governing the action of NO are likely different from those applying to locally-acting, fast neurotransmitters, whose influence is exerted chiefly within single-synapse domains (Rusakov et al. 1999). Monoamine neurotransmitters, such as 5-hydroxytryptamine, which is probably able to influence structures within a range of tens of micrometers, might be analogous Bunin and Wightman (1999). However, for the monoamines, neural cells are differentially equipped with different classes of surface receptors coupled to different transduction pathways, allowing a selectivity of action. The major receptor for NO, soluble guanylyl cyclase (sGC), however, appears to display limited molecular heterogeneity and yet has a wide distribution complementary to that of NO synthase (NOS; Furuyama et al. 1993; Southam and Garthwaite 1993). How NO achieves selectivity of action in this scenario is one of the important questions still to be answered satisfactorily." @default.
- W103631041 created "2016-06-24" @default.
- W103631041 creator A5029996303 @default.
- W103631041 date "2000-01-01" @default.
- W103631041 modified "2023-09-27" @default.
- W103631041 title "The Physiological Roles of Nitric Oxide in the Central Nervous System" @default.
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