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- W103638124 abstract "Serotonin (5-HT) is a neurohumoral indoleamine distributed in the mammalian organism. This chapter discusses the physiologic or drug-induced regulation of 5-HT synthesis and levels in the central nervous system. 5-HT is derived from dietary tryptophan by a two-step enzymic pathway. The two major factors in the control of 5-HT synthesis are the amount of tryptophan hydroxylase and the available concentration of the substrate tryptophan. The elevation of plasma and cerebral tryptophan results in an increase in the levels of serotonin in the brain. The type of inhibition of tryptophan hydroxylase that results when parachlorophenylalanine (PCPA) is administered to rats provides an understanding of regulation of enzyme levels in the brain. The knowledge of the properties of tryptophan hydroxylase and a complete understanding of PCPA inhibition may prove to be the basis for synthesizing new drugs for the regulation of 5-HT synthesis." @default.
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- W103638124 date "1973-01-01" @default.
- W103638124 modified "2023-09-27" @default.
- W103638124 title "PHYSIOLOGIC AND DRUG-INDUCED REGULATION OF SEROTONIN SYNTHESIS" @default.
- W103638124 doi "https://doi.org/10.1016/b978-0-12-078150-8.50013-x" @default.
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