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- W1036546823 abstract "This chapter discusses the preparation of tritium-labeled substrates. The ready availability of sodium borohydride-2-H3 makes possible simple syntheses of many substances that are labeled with tritium in specific positions. Sodium borohydride-2-H3 itself is readily prepared and, provided that it is kept dry, is a very stable substance. The solution of glucono-δ-lactone and bromothymol blue is placed in a small vessel which is stirred mechanically and kept on ice. The solution of borohydride is added to the solution of the lactone, drops at a time, over a period of 50 min. The reaction mixture is kept at a greenish-yellow color by the careful addition of 1 N H2S04. Enzymatic analysis with isocitrate dehydrogenase shows a quantitative yield in terms of the triethyloxalosuccinate, if it is assumed that the four possible stereoisomers are formed in equal proportions during the reduction. The exposure of an organic compound to solvents such as labeled water (H23O) or glacial acetic acid (CH3–COOH3) in the presence of a catalyst in a sealed tube at an elevated temperature leads to a random labeling of the compound." @default.
- W1036546823 created "2016-06-24" @default.
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- W1036546823 date "1963-01-01" @default.
- W1036546823 modified "2023-09-23" @default.
- W1036546823 title "[121] Preparation of tritium-labeled substrates" @default.
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- W1036546823 doi "https://doi.org/10.1016/0076-6879(63)06261-3" @default.
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