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• W103655203 startingPage "65" @default.
• W103655203 abstract "It has been known for sometime that a major impediment to an effective treatment for many human tumors involves the spread of the malignant tumors from the primary site to distant sites. Thus, an in-depth understanding of the biochemical and molecular mechanisms regulating tumor metastasis is of particular importance in the development of effective therapies for malignant cancer. It is becoming increasingly clear that the array of molecular regulators of tumor metastasis do not necessarily function in isolation, but are rather interconnected in a continuum of biochemical and cellular events. Understanding these unique molecular interactions involved in metastasis may provide novel approaches for the design of effective new drugs to regulate malignant human diseases. In this regard, an alternative approach for directly targeting proteolytic activity during tumor dissemination, might be to prevent the localization of these enzymes to the cell surface by blocking unique protease / integrin interactions. However, the critical keys to establishing these novel types of therapies involves an in-depth understanding of the basic molecular mechanisms that facilitate these protein-protein interactions. In this regard, we have discussed tumor metastasis in terms of molecular cooperation between integrins and a number of metastasis regulatory molecules, including growth factors and their receptors, proteolytic enzymes and their receptors, tetraspanins and extracellular matrix proteins. Understanding the functions of integrins in the context molecular cooperativity and how unique molecular associations between integrins and assessory proteins regulate cellular invasion, may shed new light on the fascinating and complex process of metastasis." @default.
• W103655203 created "2016-06-24" @default.
• W103655203 creator A5017938441 @default.
• W103655203 date "2005-12-28" @default.
• W103655203 modified "2023-09-27" @default.
• W103655203 title "Cooperative Integrin Interactions in the Regulation of Tumor Metastasis" @default.
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• W103655203 doi "https://doi.org/10.1007/0-306-47821-8_4" @default.
• W103655203 hasPublicationYear "2005" @default.
• W103655203 type Work @default.

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