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- W103655992 abstract "The major breakthroughs in the treatment of childhood acute lymphoblastic leukemia (ALL) occurred in the late 1970s and early 1980s and came mainly from empirically designed treatment concepts (Riehm et al. 1980, 1990). Recent attempts to further improve the outcome in children with this disease have concentrated on unraveling the underlying pathogenetic mechanisms. They have provided the means to discriminate subgroups of patients with different biology, and prognosis, leading to the concept of a risk-adapted treatment stratification. Hence, various determinants derived from immune-phenotype analysis (Greaves et al. 1981; Grist et al. 1989; Borowitz et al. 1990), flow cytometric determination of the cellular DNA content (Look et al. 1982; Hiddemann et al. 1986; Andreeff et al. 1986), and karyotype evaluations (Williams et al. 1982; Pui et al. 1990) have been shown to convey prognostic information. In particular, ploidy or chromosome number has proved to be a strong predictor of outcome with a favorable prognosis for patients with numerical aberrations who have more than 50 chromosomes. Structural abnormalities, on the other hand, were found to be associated with a higher frequency of relapses and a shorter remission duration (Williams et al. 1982; Pui et al. 1990; Seeker-Walker 1984). Along this line, the detection of DNA aneuploidies by means of flow cytometric determination of the cellular DNA content also proved a powerful tool with prognostic implications." @default.
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- W103655992 date "1993-01-01" @default.
- W103655992 modified "2023-09-27" @default.
- W103655992 title "DNA Aneuploidy in Childhood Acute Lymphoblastic Leukemia: Relation to Clinical Determinants and Prognosis within Four Consecutive BFM Trials" @default.
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- W103655992 doi "https://doi.org/10.1007/978-3-642-84895-7_11" @default.
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