FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1036661300> ?p ?o ?g. }

• W1036661300 endingPage "4341" @default.
• W1036661300 startingPage "4337" @default.
• W1036661300 abstract "Preclinical experiments and clinical observations suggest the potential effectiveness of selective 5-HT1F receptor agonists in migraine. Identifying compounds with enhanced selectivity is crucial to assess its therapeutic value. Replacement of the indole nucleus in 2 (LY334370) with a monocyclic phenyl ketone moiety generated potent and more selective 5-HT1F receptor agonists. Focused SAR studies around this central phenyl ring demonstrated that the electrostatic and steric interactions of the substituent with both the amide CONH group and the ketone CO group play pivotal roles in affecting the adopted conformation and thus the 5-HT1F receptor selectivity. Computational studies confirmed the observed results and provide a useful tool in the understanding of the conformational requirements for 5-HT1F receptor agonist activity and selectivity. Through this effort, the 2-F-phenyl and N-2-pyridyl series were also identified as potent and selective 5-HT1F receptor agonists." @default.
• W1036661300 created "2016-06-24" @default.
• W1036661300 creator A5014708668 @default.
• W1036661300 creator A5017223253 @default.
• W1036661300 creator A5021336837 @default.
• W1036661300 creator A5022661281 @default.
• W1036661300 creator A5031222473 @default.
• W1036661300 creator A5037390595 @default.
• W1036661300 creator A5037723105 @default.
• W1036661300 creator A5046142242 @default.
• W1036661300 creator A5047618629 @default.
• W1036661300 creator A5048949995 @default.
• W1036661300 creator A5053829076 @default.
• W1036661300 creator A5058156323 @default.
• W1036661300 creator A5059087611 @default.
• W1036661300 creator A5065085290 @default.
• W1036661300 creator A5065949981 @default.
• W1036661300 creator A5071637884 @default.
• W1036661300 creator A5079119716 @default.
• W1036661300 creator A5083580933 @default.
• W1036661300 creator A5086910424 @default.
• W1036661300 date "2015-10-01" @default.
• W1036661300 modified "2023-10-17" @default.
• W1036661300 title "Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT1F receptor agonists: Evolution from bicyclic to monocyclic cores" @default.
• W1036661300 cites W1976782762 @default.
• W1036661300 cites W1984868484 @default.
• W1036661300 cites W1993250823 @default.
• W1036661300 cites W2014001501 @default.
• W1036661300 cites W2036466367 @default.
• W1036661300 cites W2037558289 @default.
• W1036661300 cites W2057335558 @default.
• W1036661300 cites W2063982163 @default.
• W1036661300 cites W2067142526 @default.
• W1036661300 cites W2076112372 @default.
• W1036661300 cites W2099673580 @default.
• W1036661300 cites W2110701887 @default.
• W1036661300 cites W2123127156 @default.
• W1036661300 cites W2123630123 @default.
• W1036661300 cites W2146364656 @default.
• W1036661300 cites W2158063268 @default.
• W1036661300 cites W2164742165 @default.
• W1036661300 cites W2178054011 @default.
• W1036661300 cites W2203927838 @default.
• W1036661300 cites W2334340415 @default.
• W1036661300 doi "https://doi.org/10.1016/j.bmcl.2015.07.042" @default.
• W1036661300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26271587" @default.
• W1036661300 hasPublicationYear "2015" @default.
• W1036661300 type Work @default.
• W1036661300 sameAs 1036661300 @default.
• W1036661300 citedByCount "6" @default.
• W1036661300 countsByYear W10366613002017 @default.
• W1036661300 countsByYear W10366613002019 @default.
• W1036661300 countsByYear W10366613002020 @default.
• W1036661300 countsByYear W10366613002023 @default.
• W1036661300 crossrefType "journal-article" @default.
• W1036661300 hasAuthorship W1036661300A5014708668 @default.
• W1036661300 hasAuthorship W1036661300A5017223253 @default.
• W1036661300 hasAuthorship W1036661300A5021336837 @default.
• W1036661300 hasAuthorship W1036661300A5022661281 @default.
• W1036661300 hasAuthorship W1036661300A5031222473 @default.
• W1036661300 hasAuthorship W1036661300A5037390595 @default.
• W1036661300 hasAuthorship W1036661300A5037723105 @default.
• W1036661300 hasAuthorship W1036661300A5046142242 @default.
• W1036661300 hasAuthorship W1036661300A5047618629 @default.
• W1036661300 hasAuthorship W1036661300A5048949995 @default.
• W1036661300 hasAuthorship W1036661300A5053829076 @default.
• W1036661300 hasAuthorship W1036661300A5058156323 @default.
• W1036661300 hasAuthorship W1036661300A5059087611 @default.
• W1036661300 hasAuthorship W1036661300A5065085290 @default.
• W1036661300 hasAuthorship W1036661300A5065949981 @default.
• W1036661300 hasAuthorship W1036661300A5071637884 @default.
• W1036661300 hasAuthorship W1036661300A5079119716 @default.
• W1036661300 hasAuthorship W1036661300A5083580933 @default.
• W1036661300 hasAuthorship W1036661300A5086910424 @default.
• W1036661300 hasConcept C118792377 @default.
• W1036661300 hasConcept C161790260 @default.
• W1036661300 hasConcept C170493617 @default.
• W1036661300 hasConcept C178790620 @default.
• W1036661300 hasConcept C185592680 @default.
• W1036661300 hasConcept C21951064 @default.
• W1036661300 hasConcept C24961977 @default.
• W1036661300 hasConcept C2776568683 @default.
• W1036661300 hasConcept C2777738585 @default.
• W1036661300 hasConcept C2778439535 @default.
• W1036661300 hasConcept C2778689049 @default.
• W1036661300 hasConcept C2778938600 @default.
• W1036661300 hasConcept C55493867 @default.
• W1036661300 hasConcept C71240020 @default.
• W1036661300 hasConceptScore W1036661300C118792377 @default.
• W1036661300 hasConceptScore W1036661300C161790260 @default.
• W1036661300 hasConceptScore W1036661300C170493617 @default.
• W1036661300 hasConceptScore W1036661300C178790620 @default.
• W1036661300 hasConceptScore W1036661300C185592680 @default.
• W1036661300 hasConceptScore W1036661300C21951064 @default.
• W1036661300 hasConceptScore W1036661300C24961977 @default.
• W1036661300 hasConceptScore W1036661300C2776568683 @default.
• W1036661300 hasConceptScore W1036661300C2777738585 @default.
• W1036661300 hasConceptScore W1036661300C2778439535 @default.

• next