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- W1036700737 abstract "The cellular prion protein (PrP(C)) has been associated with a plethora of cellular functions ranging from cell cycle to neuroprotection. Mice lacking PrP(C) show an increased susceptibility to epileptic seizures; the protein, then, is neuroprotective. However, lack of experimental reproducibility has led to considering the possibility that other factors besides PrP(C) deletion, such as the genetic background of mice or the presence of so-called Prnp flanking genes, might contribute to the reported susceptibility. Here, we performed a comparative analysis of seizure-susceptibility using characterized Prnp(+/+) and Prnp(0/0) mice of B6129, B6.129, 129/Ola or FVB/N genetic backgrounds. Our study indicates that PrP(C) plays a role in neuroprotection in KA-treated cells and mice. For this function, PrP(C) should contain the aa32-93 region and needs to be linked to the membrane. In addition, some unidentified Prnp-flanking genes play a role parallel to PrP(C) in the KA-mediated responses in B6129 and B6.129 Prnp(0/0) mice." @default.
- W1036700737 created "2016-06-24" @default.
- W1036700737 creator A5006285239 @default.
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- W1036700737 creator A5059759705 @default.
- W1036700737 creator A5068669818 @default.
- W1036700737 date "2015-07-09" @default.
- W1036700737 modified "2023-10-14" @default.
- W1036700737 title "Involvement of PrPC in kainate-induced excitotoxicity in several mouse strains" @default.
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