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• W103670294 abstract "Prostate-specific antigen (PSA) has been accepted as a useful tumor marker for early diagnosis, staging, follow-up, and response to therapy of prostate cancer patients. In the last 20 years, widespread use of PSA testing has led to a remarkable increase in the incidence of prostate cancer, detection of the disease in early stages, and a reduction in mortality. Regardless of its impressive performance in the management of prostatic diseases, PSA testing has several limitations. PSA is an organ-specific marker but not disease specific. Therefore, PSA levels of men with or without prostate cancer can overlap especially in the range of 4.0–10.0 ng/mL. On the other hand, a significant number of men with PSA levels of less than 4.0 ng/mL have been diagnosed with prostate cancer. To overcome these limitations and improve the specificity of PSA testing, several molecular derivatives and isoforms have been identified. Another issue in question is the value of PSA screening and the overdiagnosis of potentially indolent cancer. Recently, the effect of PSA screening on prostate cancer mortality has been evaluated in two large prospective randomized trials, which will be discussed in detail. The following chapter will focus on the current status of PSA testing as a screening tool and recent progress to improve the utility of this marker for detection, staging, and follow-up of prostate cancer patients." @default.
• W103670294 created "2016-06-24" @default.
• W103670294 creator A5064473276 @default.
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• W103670294 date "2012-01-01" @default.
• W103670294 modified "2023-09-27" @default.
• W103670294 title "Twenty Years and Counting: Is PSA Still Useful in 2010?" @default.
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• W103670294 doi "https://doi.org/10.1007/978-1-60761-259-9_2" @default.
• W103670294 hasPublicationYear "2012" @default.
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