FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W103675497> ?p ?o ?g. }

• W103675497 endingPage "890" @default.
• W103675497 startingPage "883" @default.
• W103675497 abstract "This study sought to evaluate vascular drug uptake, distribution and response of second-generation paclitaxel coated balloon (PCB) (Cotavance, MEDRAD Interventional, Indianola, Pennsylvania) and compare it with first-generation technology, containing identical excipient and drug concentration. Original PCB technologies displayed a heterogeneous deposition of crystalline paclitaxel-iopromide inside the balloon folds, whereas second-generation PCBs consisted of more homogeneous, circumferential coatings. Paclitaxel tissue uptake was assessed in 20 iliofemoral arteries of a domestic swine. Vascular healing response was assessed in the familial hypercholesterolemic model of iliofemoral in-stent restenosis. Three weeks after bare-metal stent implantation, vascular segments were randomly revascularized with first-generation PCBs (n = 6), second-generation PCBs (n = 6), or plain balloon angioplasty (PBA) (n = 6). At 28 days, angiographic and histological evaluation was performed in all treated segments. One-hour paclitaxel tissue uptake was 42% higher in the second-generation PCBs (p = 0.03) and resulted in more homogeneous segment-to-segment distribution compared with first-generation PCBs. Both angiography (percentage of diameter stenosis: second-generation 11.5 ± 11% vs. first-generation 21.9 ± 11% vs. PBA 46.5 ± 10%; p < 0.01) and histology (percentage of area stenosis: second-generation 50.5 ± 7% vs. first-generation 54.8 ± 18% vs. PBA 78.2 ± 9%; p < 0.01) showed a decrease in neointimal proliferation in both PCB groups. Histological variance of the percentage of area stenosis was lower in second-generation compared with first-generation PCBs (51.7 vs. 328.3; p = 0.05). The presence of peristrut fibrin deposits (0.5 vs. 2.4; p < 0.01) and medial smooth muscle cell loss (0 vs. 1.7; p < 0.01) were lower in the second-generation compared with first-generation PCBs. In the experimental setting, second-generation PCB showed a comparable efficacy profile and more favorable vascular healing response when compared to first-generation PCB. The clinical implications of these findings require further investigation." @default.
• W103675497 created "2016-06-24" @default.
• W103675497 creator A5005405403 @default.
• W103675497 creator A5005544971 @default.
• W103675497 creator A5010243179 @default.
• W103675497 creator A5033556349 @default.
• W103675497 creator A5037567736 @default.
• W103675497 creator A5041821457 @default.
• W103675497 creator A5044151526 @default.
• W103675497 creator A5079798182 @default.
• W103675497 creator A5085318496 @default.
• W103675497 creator A5091895141 @default.
• W103675497 date "2013-08-01" @default.
• W103675497 modified "2023-10-11" @default.
• W103675497 title "Tissue Uptake, Distribution, and Healing Response After Delivery of Paclitaxel via Second-Generation Iopromide-Based Balloon Coating" @default.
• W103675497 cites W1523112201 @default.
• W103675497 cites W1895932837 @default.
• W103675497 cites W1964910773 @default.
• W103675497 cites W1975375588 @default.
• W103675497 cites W1976235521 @default.
• W103675497 cites W1977066990 @default.
• W103675497 cites W2007488605 @default.
• W103675497 cites W2008850799 @default.
• W103675497 cites W2010094572 @default.
• W103675497 cites W2011311905 @default.
• W103675497 cites W2012105182 @default.
• W103675497 cites W2014111193 @default.
• W103675497 cites W2021526294 @default.
• W103675497 cites W2028425022 @default.
• W103675497 cites W2029660039 @default.
• W103675497 cites W2029927648 @default.
• W103675497 cites W2056573415 @default.
• W103675497 cites W2064879907 @default.
• W103675497 cites W2074919956 @default.
• W103675497 cites W2101163090 @default.
• W103675497 cites W2102528608 @default.
• W103675497 cites W2109769695 @default.
• W103675497 cites W2120194944 @default.
• W103675497 cites W2132880199 @default.
• W103675497 cites W2883874260 @default.
• W103675497 doi "https://doi.org/10.1016/j.jcin.2013.04.013" @default.
• W103675497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23968706" @default.
• W103675497 hasPublicationYear "2013" @default.
• W103675497 type Work @default.
• W103675497 sameAs 103675497 @default.
• W103675497 citedByCount "39" @default.
• W103675497 countsByYear W1036754972013 @default.
• W103675497 countsByYear W1036754972015 @default.
• W103675497 countsByYear W1036754972016 @default.
• W103675497 countsByYear W1036754972017 @default.
• W103675497 countsByYear W1036754972018 @default.
• W103675497 countsByYear W1036754972019 @default.
• W103675497 countsByYear W1036754972020 @default.
• W103675497 countsByYear W1036754972021 @default.
• W103675497 countsByYear W1036754972022 @default.
• W103675497 countsByYear W1036754972023 @default.
• W103675497 crossrefType "journal-article" @default.
• W103675497 hasAuthorship W103675497A5005405403 @default.
• W103675497 hasAuthorship W103675497A5005544971 @default.
• W103675497 hasAuthorship W103675497A5010243179 @default.
• W103675497 hasAuthorship W103675497A5033556349 @default.
• W103675497 hasAuthorship W103675497A5037567736 @default.
• W103675497 hasAuthorship W103675497A5041821457 @default.
• W103675497 hasAuthorship W103675497A5044151526 @default.
• W103675497 hasAuthorship W103675497A5079798182 @default.
• W103675497 hasAuthorship W103675497A5085318496 @default.
• W103675497 hasAuthorship W103675497A5091895141 @default.
• W103675497 hasBestOaLocation W1036754971 @default.
• W103675497 hasConcept C126838900 @default.
• W103675497 hasConcept C136229726 @default.
• W103675497 hasConcept C139059822 @default.
• W103675497 hasConcept C141071460 @default.
• W103675497 hasConcept C2776694085 @default.
• W103675497 hasConcept C2777292972 @default.
• W103675497 hasConcept C2778283817 @default.
• W103675497 hasConcept C2778583881 @default.
• W103675497 hasConcept C2778754328 @default.
• W103675497 hasConcept C2779786684 @default.
• W103675497 hasConcept C2780007028 @default.
• W103675497 hasConcept C2780326628 @default.
• W103675497 hasConcept C2908647359 @default.
• W103675497 hasConcept C2989005 @default.
• W103675497 hasConcept C2992829110 @default.
• W103675497 hasConcept C71924100 @default.
• W103675497 hasConcept C99454951 @default.
• W103675497 hasConceptScore W103675497C126838900 @default.
• W103675497 hasConceptScore W103675497C136229726 @default.
• W103675497 hasConceptScore W103675497C139059822 @default.
• W103675497 hasConceptScore W103675497C141071460 @default.
• W103675497 hasConceptScore W103675497C2776694085 @default.
• W103675497 hasConceptScore W103675497C2777292972 @default.
• W103675497 hasConceptScore W103675497C2778283817 @default.
• W103675497 hasConceptScore W103675497C2778583881 @default.
• W103675497 hasConceptScore W103675497C2778754328 @default.
• W103675497 hasConceptScore W103675497C2779786684 @default.
• W103675497 hasConceptScore W103675497C2780007028 @default.
• W103675497 hasConceptScore W103675497C2780326628 @default.
• W103675497 hasConceptScore W103675497C2908647359 @default.

• next