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• W103677414 abstract "Multiple sequence alignment (MSA) is an essential tool with many applications in bioinformatics and computational biology. Accurate MSA construction for divergent proteins remains a difficult computational task. The constantly increasing protein sequences and structures in public databases could be used to improve alignment quality. PROMALS3D is a tool for protein MSA construction enhanced with additional evolutionary and structural information from database searches. PROMALS3D automatically identifies homologs from sequence and structure databases for input proteins, derives structure-based constraints from alignments of three-dimensional structures, and combines them with sequence-based constraints of profile–profile alignments in a consistency-based framework to construct high-quality multiple sequence alignments. PROMALS3D output is a consensus alignment enriched with sequence and structural information about input proteins and their homologs. PROMALS3D Web server and package are available at http://prodata.swmed.edu/PROMALS3D ." @default.
• W103677414 created "2016-06-24" @default.
• W103677414 creator A5037320644 @default.
• W103677414 creator A5039591575 @default.
• W103677414 date "2013-08-23" @default.
• W103677414 modified "2023-10-04" @default.
• W103677414 title "PROMALS3D: Multiple Protein Sequence Alignment Enhanced with Evolutionary and Three-Dimensional Structural Information" @default.
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• W103677414 doi "https://doi.org/10.1007/978-1-62703-646-7_17" @default.
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