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- W1036898508 abstract "The first interactions between endothelium and dendritic cells (DCs) precursors occur when these precursors are recruited to tissues and extravasate across vascular endothelium. Vascular endothelium regulates the passage of leukocytes from blood to tissues via the coordinated and selective expression of chemokines and the expression of adhesive selectins and ligands for leukocytic integrins. Clearance of DCs from tissues as they carry processed antigen to lymphoid organs requires migration across an endothelial barrier in the ablumenal-to-lumenal direction. Monocyte-derived cells reverse transmigrate across cultured vascular endothelium in cultures of human umbilical vein endothelial cells (HUVECs) or dermal microvascular endothelium grown on native human connective tissue, reconstituted collagen gels, or polycarbonate filters. There are several molecular markers that may identify subsets of blood cells that preferentially reverse transmigrate and become DCs." @default.
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- W1036898508 date "2001-01-01" @default.
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- W1036898508 title "Endothelium" @default.
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- W1036898508 doi "https://doi.org/10.1016/b978-012455851-9/50060-2" @default.
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