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- W1036989719 abstract "A 2005-ben befejezett munka soran szeles kiserleti hattere, kulonboző sejtes modellekre alapozva szisztematikus munkaval igazoltuk az un membran szenzor hipotezis univerzalis ervenyesseget. A stresszfeherje chaperon) valasz sejt- es molekularis hatterenek egy teljesen uj aspektusat tartuk fel, amikor is a stresszvalasz primer jelkepző funkciojat nem a proteotoxicitas, hanem a membranok lipidfazisa altal kontrolalt allapotvaltozasok latjak el. A membranok lipid-lipid ill. lipid-feherje kolcsonhatasaiban (molekularis kapcsolok) stressz (pld. magashőmerseklet) altal kivaltott valtozasokat a membranok feherje es lipidosszetetelenek ill. mikrodomen szintű finomszerveződesenek szintjen kovettuk. Igazoltuk a stresszfeherjek lipidmedialta kolcsonhatasait. Kutatasaink ujgeneracios gyogyszerek (pld. hidroximsavszarmazekok) kifejleszteset alapoztak meg. Ezek a stresszfeherje szintezis megfelelő kontrolljaval olyan patologias allapotok gyogyitasat teszik lehetőve, mint a 2. tipusu diabetesz, vagy a neurodegenerativ betegsegek. | Based on broad experimental approaches and different cellular models in the course of the realization of this OTKA project we provided evidences on the universal validity of the ?membrane sensor? hypothesis. We explored a novel aspect of stress protein response by highlighting those conditions (mild heat stress, membrane defects in disease states, aging, etc.) under which the primary cellular stress sensing mechanism operates by subtle, lipid-phase controlled membrane alterations, rather than by massive proteotoxicity (severe stress). Membrane changes induced by various stress conditions (likely governed by lipid-lipid and lipid-protein interactions) were systematically monitored by real-time single molecule microscopy and coupled to the downstream signaling pathways, leading ultimately to hsp transcription. We have shown, that stress proteins are capable to transport and translocate to the lipid phase of membranes. Our investigations opened the door for the development of a new-generation of drugs. There mode of action is linked to the normalization of dysregulated stress protein response in disease states, like type2 diabetes or neurodegenerative diseases." @default.
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- W1036989719 date "2006-01-01" @default.
- W1036989719 modified "2023-10-05" @default.
- W1036989719 title "Stresszválasz: membrántól membránig = Stress response: from membrane to membrane" @default.
- W1036989719 hasPublicationYear "2006" @default.
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