Matches in SemOpenAlex for { <https://semopenalex.org/work/W103726488> ?p ?o ?g. }
- W103726488 abstract "Disruptions in methyl group metabolism have been associated with a number of disease states, including birth defects, cardiovascular disease, and neurological disorders. Therefore, characterization of the factors that regulate folate and methyl group supply is essential for the development of disease treatments and prevention. Glycine N-methyltransferase (GNMT), an enzyme essential to methyl group balance, is markedly increased by retinoic acid treatment. Furthermore, retinoid therapy has been shown to impact neurotransmitter metabolism, thereby contributing to the development of major depressive disorder. Recently, it has been shown that depressed patients have low levels of folate, other B-vitamins, and S-adenosyl methionine (SAM), all compounds essential for maintaining effective methyl group metabolism. The following studies were conducted to further characterize the impact of oral retinoic acid administration, and to investigate the potential prevention of any detrimental effects by administering oral SAM. In the preliminary study (Chapter 2), as expected, GNMT activity was significantly increased in rats receiving all-trans retinoic acid (ATRA). Additionally, whole brain serotonin levels were decreased by 46% in rats receiving ATRA, an effect that was partially attenuated by oral" @default.
- W103726488 created "2016-06-24" @default.
- W103726488 creator A5016339293 @default.
- W103726488 date "2018-08-10" @default.
- W103726488 modified "2023-09-26" @default.
- W103726488 title "Oral S-adenosyl methionine (SAM) mediates disruptions in methyl group metabolism due to retinoic acid therapy and alters neurotransmitter metabolism: implications for major depressive disorder" @default.
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