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- W1037266911 abstract "Insulin and insulin-like growth factors 1 and 2 (Igf1 and Igf2, respectively) are genetically and functionally related peptides with overlapping anabolic and growth-promoting effects (1,2). The actions of insulin are mediated by the insulin receptor, a membrane-bound tyrosine kinase which is activated by ligand binding (3). The actions of both Igfl and 2 are mediated for the most part by the homologous Igf 1 receptor, which engages many of the same intracellular signaling pathways as the insulin receptor (4,5). An Igf2/ mannose-6-phosphate receptor, binds Igf2 and promotes its degradation in the lyzosomal pathway (6). During the past decade, each of these ligands and receptors have been subjected to targeted gene deletions, providing novel insights into growth regulation and ligand-receptor interactions in murine embryonic and postnatal development. This chapter focuses on the developmental and physiological consequences of deletions of Igf1, Igf2, insulin, and the Igf1 and insulin receptors, alone and in combination." @default.
- W1037266911 created "2016-06-24" @default.
- W1037266911 creator A5017924277 @default.
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- W1037266911 date "2001-01-01" @default.
- W1037266911 modified "2023-10-17" @default.
- W1037266911 title "Insulin and Insulin-Like Growth Factors" @default.
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- W1037266911 doi "https://doi.org/10.1007/978-1-59259-102-2_17" @default.
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