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• W1039049381 startingPage "145" @default.
• W1039049381 abstract "The studies in this chapter have been undertaken to better define which specific aspects of myocardial SR function are altered by anesthetics. The major result of the present study concerns the modest but distinct effects of the halogenated volatile anesthetics on Ca2+ uptake and retention of isolated myocardial sarcoplasmic reticulum (SR) function at clinically relevant concentrations. The differing functional changes appear to arise from agent-specific actions on the ATPase activity as well as the ability of vesicles to retain accumulated Ca2+. The present results more clearly define the huge propensity for halothane to depress Ca2+ uptake to a greater extent than isoflurane. The depression in Ca2+ uptake is associated with a compensatory rise in ATPase activity, similar to the effect of an increase from pH 7.0 to pH 7.4 attributable to enhanced efflux. Additional effects of halothane in promoting Ca2+ loss from the SR may well include its activation of the Ca2+ release channel (CaRC). In contrast, Ca2+ uptake is only modestly decreased by isoflurane, a finding consistent with other studies in myocardial tissue that suggest isoflurane has less effect on Ca2+ stores. However, none of the anesthetics depressed the ATPase activity. The most curious effect is the increase in ATPase activity and Ca2+ uptake caused by enflurane. In addition to the aforementioned anesthetic actions, there are in junctional SR additional differential effects of the anesthetics on the CaRC of cardiac SR. In isolated myocardium, enflurane has depressant effects on contractily that frequently fall between those of halothane and isoflurane, but in the absence of a detailed model of myocyte Ca2+ cycling it is unclear how the various effects on SR will combine with other anesthetic effects." @default.
• W1039049381 created "2016-06-24" @default.
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• W1039049381 date "1994-01-01" @default.
• W1039049381 modified "2023-09-26" @default.
• W1039049381 title "Anesthetic Actions on Calcium Uptake and Calcium-Dependent Adenosine Triphosphatase Activity of Cardiac Sarcoplasmic Reticulum" @default.
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• W1039049381 doi "https://doi.org/10.1016/s1054-3589(08)60614-6" @default.
• W1039049381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7873409" @default.
• W1039049381 hasPublicationYear "1994" @default.
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