Matches in SemOpenAlex for { <https://semopenalex.org/work/W10395890> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W10395890 endingPage "12" @default.
- W10395890 startingPage "7" @default.
- W10395890 abstract "The radical treatment currently for decompensated liver cirrhosis is still liver transplantation. However, liver transplants are not widely performed worldwide and development of genuine regeneration therapy for liver cirrhosis is an urgent task. We have developed a novel murine model [the green fluorescent protein (GFP)/carbon tetrachloride (CCl4) model], and reported that infused GFP-positive bone marrow cells repopulated cirrhotic liver. Moreover, repopulated bone marrow cells ameliorated liver fibrosis through higher expression of matrix metalloproteinase-9, consistent with improved liver functions and better survival rate. Based on these findings, we started a clinical trial of autologous bone marrow cell infusion (ABMi) therapy for decompensated liver cirrhotic patients, and reported the efficacy and the safety of this approach. On the other hand, various other clinical studies for liver disease have been also reported, including hepatic administration of autologous CD34-positive cells induced by granulocyte colony-stimulating factor (G-CSF), portal vein administration of CD133-positive mononuclear cells, and administration of autologous bone marrow derived mesenchymal stem cells (MSCs). Effectiveness of these approaches has been shown in some patients. We provided here an overview of the current status of liver regeneration therapies including our results of the murine GFP/CCl4 model and ABMi therapy for liver cirrhosis and future prospects." @default.
- W10395890 created "2016-06-24" @default.
- W10395890 creator A5021394925 @default.
- W10395890 creator A5082111082 @default.
- W10395890 creator A5085571910 @default.
- W10395890 date "2012-07-01" @default.
- W10395890 modified "2023-09-26" @default.
- W10395890 title "Advanced therapies using autologous bone marrow cells for chronic liver disease." @default.
- W10395890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22846198" @default.
- W10395890 hasPublicationYear "2012" @default.
- W10395890 type Work @default.
- W10395890 sameAs 10395890 @default.
- W10395890 citedByCount "10" @default.
- W10395890 countsByYear W103958902014 @default.
- W10395890 countsByYear W103958902015 @default.
- W10395890 countsByYear W103958902016 @default.
- W10395890 countsByYear W103958902017 @default.
- W10395890 countsByYear W103958902019 @default.
- W10395890 countsByYear W103958902020 @default.
- W10395890 crossrefType "journal-article" @default.
- W10395890 hasAuthorship W10395890A5021394925 @default.
- W10395890 hasAuthorship W10395890A5082111082 @default.
- W10395890 hasAuthorship W10395890A5085571910 @default.
- W10395890 hasConcept C10205521 @default.
- W10395890 hasConcept C126322002 @default.
- W10395890 hasConcept C142724271 @default.
- W10395890 hasConcept C171056886 @default.
- W10395890 hasConcept C198826908 @default.
- W10395890 hasConcept C2776795407 @default.
- W10395890 hasConcept C2777075537 @default.
- W10395890 hasConcept C2777214474 @default.
- W10395890 hasConcept C2779102576 @default.
- W10395890 hasConcept C2780007613 @default.
- W10395890 hasConcept C28328180 @default.
- W10395890 hasConcept C502942594 @default.
- W10395890 hasConcept C54355233 @default.
- W10395890 hasConcept C71924100 @default.
- W10395890 hasConcept C86803240 @default.
- W10395890 hasConcept C95444343 @default.
- W10395890 hasConceptScore W10395890C10205521 @default.
- W10395890 hasConceptScore W10395890C126322002 @default.
- W10395890 hasConceptScore W10395890C142724271 @default.
- W10395890 hasConceptScore W10395890C171056886 @default.
- W10395890 hasConceptScore W10395890C198826908 @default.
- W10395890 hasConceptScore W10395890C2776795407 @default.
- W10395890 hasConceptScore W10395890C2777075537 @default.
- W10395890 hasConceptScore W10395890C2777214474 @default.
- W10395890 hasConceptScore W10395890C2779102576 @default.
- W10395890 hasConceptScore W10395890C2780007613 @default.
- W10395890 hasConceptScore W10395890C28328180 @default.
- W10395890 hasConceptScore W10395890C502942594 @default.
- W10395890 hasConceptScore W10395890C54355233 @default.
- W10395890 hasConceptScore W10395890C71924100 @default.
- W10395890 hasConceptScore W10395890C86803240 @default.
- W10395890 hasConceptScore W10395890C95444343 @default.
- W10395890 hasIssue "74" @default.
- W10395890 hasLocation W103958901 @default.
- W10395890 hasOpenAccess W10395890 @default.
- W10395890 hasPrimaryLocation W103958901 @default.
- W10395890 hasRelatedWork W2056987962 @default.
- W10395890 hasRelatedWork W2065863952 @default.
- W10395890 hasRelatedWork W2071333517 @default.
- W10395890 hasRelatedWork W2132069939 @default.
- W10395890 hasRelatedWork W2171075518 @default.
- W10395890 hasRelatedWork W2332279058 @default.
- W10395890 hasRelatedWork W2351674966 @default.
- W10395890 hasRelatedWork W2613759826 @default.
- W10395890 hasRelatedWork W2979442529 @default.
- W10395890 hasRelatedWork W2152237187 @default.
- W10395890 hasVolume "14" @default.
- W10395890 isParatext "false" @default.
- W10395890 isRetracted "false" @default.
- W10395890 magId "10395890" @default.
- W10395890 workType "article" @default.