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- W1040133247 endingPage "461" @default.
- W1040133247 startingPage "451" @default.
- W1040133247 abstract "Since their identification by Steinman and Cohn over 30 years ago, dendritic cells (DCs) have been shown to play a central role in the initiation and control of the protective host immune response to pathogens. Recent advances in the understanding of the interactions between DCs and Mycobacterium tuberculosis and how these interactions affect the course of immune activation and induction of protection against infection are reviewed. Phagocytosis of particulate material and intact organisms occurs by receptor-mediated endocytosis. Engagement of costimulatory molecules by CD28 expressed on the surface of the T cells leads to recruitment of membrane rafts containing kinases and adapters to the immunological synapse, thus amplifying by up to 100-fold the signaling process started by T-cell receptor engagement. The importance of this cytokine in regulating the immune response is highlighted by the observation that individuals with germ line mutations in genes of the interleukin-12 (IL-12) receptor and signaling pathway (that result in defective activity) have an increased risk of contracting mycobacterial diseases, including tuberculosis. Despite increasing knowledge about the interaction between M. tuberculosis and DCs in vitro, relatively little is known about the sequence of events during infection with M. tuberculosis in vivo. Researchers have recently initiated studies to compare the number and function of blood DCs in human immunodeficiency virus-seronegative adults with various clinical presentations of tuberculosis (TB)." @default.
- W1040133247 created "2016-06-24" @default.
- W1040133247 creator A5015195207 @default.
- W1040133247 creator A5045325917 @default.
- W1040133247 creator A5090415157 @default.
- W1040133247 date "2004-12-13" @default.
- W1040133247 modified "2023-09-23" @default.
- W1040133247 title "Dendritic Cells in Host Immunity to Mycobacterium tuberculosis" @default.
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