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- W10401916 abstract "We studied in the mutagenicity of three aromatic amines in a lacZ reversion assay in E. coli: 2-nitrofluorene (NF), N-2-acetylaminofluorene (AAF), and N-hydroxy-N-2-acetylaminofluorene (NHA). Mutations that confer the Lac{sup +} phenotype were measured using an F{prime} factor from strain CC109 of Cupples et al. The F{prime} contains a lacZ mutation that reverts by a -2 frameshift at a site of repetitive dinucleotides (CG{sub 5} to CG{sub 4}). The F{prime} was transferred into strains carrying an LPS{sup d} mutation that increases permeability to aromatic amines and a plasmid (pYG219) that contains the Salmonella nat gene, which confers N- and O-acetyltransferase (NAT/OAT) activity. Mutagenesis was measured by papillation assays and quantitative reversion assays. The results show that the LPS{sup d} mutation, conferring enhanced permeability, facilitates measuring the mutagenicity of aromatic amines but is not absolutely required, in that a lower level of mutagenicity is detected in LPS{sup +} strains. The NAT/OAT activity conferred by pYG219 strongly potentiates the mutagenicity of NF and NHA. The mutagenicity of NF is undoubtedly ascribable to aminofluorene (AF) adducts: The mutagenicity of NHA may be due either to AAF adducts or to AF adducts produced by deacetylation. Surprisingly, AAF was weakly mutagenic in a NAT/OAT LPS{sup d}more » strain even without metabolic activation by a mammalian cytochrome P450.« less" @default.
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- W10401916 date "1997-10-01" @default.
- W10401916 modified "2023-09-23" @default.
- W10401916 title "Frameshift mutagenicity of aromatic amines related to aminofluorene in a lacZ reversion assay in E. coli" @default.
- W10401916 hasPublicationYear "1997" @default.
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