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- W104036718 endingPage "407" @default.
- W104036718 startingPage "389" @default.
- W104036718 abstract "Circadian clocks are endogenous oscillators that drive the rhythmic expression of a broad array of genes that orchestrate metabolism and physiology. Recent evidence indicates that posttranscriptional and posttranslational mechanisms play essential roles in modulating circadian gene expression, particularly for the molecular mechanism of the clock. In contrast to genetic technologies that have long been used to study circadian biology, proteomic approaches have so far been limited and, if applied at all, have used two-dimensional gel electrophoresis (2-DE). Here, we review the proteomics approaches applied to date in the circadian field, and we also discuss the exciting potential of using cutting-edge proteomics technology in circadian biology. Large-scale, quantitative protein abundance measurements will help to understand to what extent the circadian clock drives system wide rhythms of protein abundance downstream of transcription regulation." @default.
- W104036718 created "2016-06-24" @default.
- W104036718 creator A5012333174 @default.
- W104036718 creator A5090940750 @default.
- W104036718 date "2013-01-01" @default.
- W104036718 modified "2023-09-27" @default.
- W104036718 title "Proteomic Approaches in Circadian Biology" @default.
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