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- W104044788 abstract "Abstract - Estimating acceptably exposure limits for potentially dangerous substances is common to many public and environmental health fields. Scientific data, reproducible in nature, forms the foundation, but the estimate is essentially the product of informed judgment even when expressed as a finite number such as a threshold limit value for the work environment or a maximum residue limit for pesticides in food. Guideposts are required to evaluate the usefulness of the estimated limits and for the evaluation of the judgmental processes used in their establishment. For pesticide residues in food, one guidepost is the Acceptable Daily Intake (ADI) defined as the daily exposure level of a pesticide residue which, during the entire lifetime of man, appears to be without appreciable risk on the basis of all facts known at the time. The ADI is expressed in milligrams of pesticide, as it appears in the diet, per kilogram of body weight per day (mg/kg/day). “Without appreciable risk” is taken to mean the practical certainty that injury will not result even after a lifetime of exposure. Two characteristics are recognizable, the ADI is dynamic based on known facts at the time of calculation and therefore subject to change by newer facts, and its usefulness is limited by the debatable judgmental concept of appreciable risk. The quantifiable nature of the ADI lies for the most part in the reliability of the known facts. Discussion of the methodologies will reveal some of the errors inherent in the development of the ADI and some of the errors in application of the concept to evaluation of maximum residue limits for pesticides. In spite of its limitations the ADI is useful and should not be discarded simply on the basis of misapplication." @default.
- W104044788 created "2016-06-24" @default.
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- W104044788 date "1979-01-01" @default.
- W104044788 modified "2023-09-27" @default.
- W104044788 title "THE ‘ACCEPTABLE DAILY INTAKE’ AS A QUANTIFIED EXPRESSION OF THE ACCEPTABILITY OF PESTICIDE RESIDUES" @default.
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- W104044788 doi "https://doi.org/10.1016/b978-0-08-023931-6.50015-1" @default.
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