Matches in SemOpenAlex for { <https://semopenalex.org/work/W1040590940> ?p ?o ?g. }
- W1040590940 endingPage "99" @default.
- W1040590940 startingPage "81" @default.
- W1040590940 abstract "The transpeptidases are members of the family of penicillin-binding proteins (PBPs), which have become known as the targets of β-lactam antibiotics. PBPs perform a variety of critical functions for the bacterial cell. PBPs are found in all pathogenic bacteria except those of the genus Mycoplasma, which do not have a cell wall. Reduced expression of PBP2 (type B, assignment not certain) is one of the most frequently observed mechanisms of resistance to carbapenems. PBP2 (type B4) and PBP3 (type B5) have been specifically implicated in resistance towards β-lactams. Increased expression of PBP4 (type C2) has been implicated in resistance to both β-lactams and glycopeptides. Hakenbeck et al. implicated the D,D-carboxypeptidase S. pneumoniae PBP3 (type C3) in resistance. PCR-based methods for the detection of antibiotic resistance are becoming increasingly important with the expanding use of molecular techniques for bacteriological diagnosis. Antibody-based tests have also been investigated for detection of methicillin resistance in staphylococci. There are several experimental β-lactams now known to be potent inhibitors of the staphylococcal type B1 PBP that is the primary determinant of β-lactam resistance in these organisms, of which ceftobiprole is the most advanced in clinical development. An understanding of the mechanism of methicillin resistance has led to the discovery of accessory factors that influence the level and nature of methicillin resistance." @default.
- W1040590940 created "2016-06-24" @default.
- W1040590940 creator A5047246055 @default.
- W1040590940 date "2014-04-30" @default.
- W1040590940 modified "2023-09-26" @default.
- W1040590940 title "Resistance Mediated by Penicillin-Binding Proteins" @default.
- W1040590940 cites W1532561872 @default.
- W1040590940 cites W1601925021 @default.
- W1040590940 cites W1645897308 @default.
- W1040590940 cites W1735924619 @default.
- W1040590940 cites W1762520094 @default.
- W1040590940 cites W1777824728 @default.
- W1040590940 cites W1890373425 @default.
- W1040590940 cites W1966306502 @default.
- W1040590940 cites W1968889738 @default.
- W1040590940 cites W1969338957 @default.
- W1040590940 cites W1969457119 @default.
- W1040590940 cites W1970188441 @default.
- W1040590940 cites W1971299795 @default.
- W1040590940 cites W1975042874 @default.
- W1040590940 cites W1976780773 @default.
- W1040590940 cites W1979438104 @default.
- W1040590940 cites W1982067034 @default.
- W1040590940 cites W1982809443 @default.
- W1040590940 cites W1983165822 @default.
- W1040590940 cites W1988001089 @default.
- W1040590940 cites W1995143470 @default.
- W1040590940 cites W1995228590 @default.
- W1040590940 cites W1995835976 @default.
- W1040590940 cites W2003244719 @default.
- W1040590940 cites W2011080054 @default.
- W1040590940 cites W2011591718 @default.
- W1040590940 cites W2015241610 @default.
- W1040590940 cites W2020855419 @default.
- W1040590940 cites W2023076146 @default.
- W1040590940 cites W2024241267 @default.
- W1040590940 cites W2029157915 @default.
- W1040590940 cites W2030568706 @default.
- W1040590940 cites W2031020095 @default.
- W1040590940 cites W2033455699 @default.
- W1040590940 cites W2036173432 @default.
- W1040590940 cites W2036989796 @default.
- W1040590940 cites W2041789230 @default.
- W1040590940 cites W2045988032 @default.
- W1040590940 cites W2048121431 @default.
- W1040590940 cites W2048435375 @default.
- W1040590940 cites W2050460020 @default.
- W1040590940 cites W2051438193 @default.
- W1040590940 cites W2056237822 @default.
- W1040590940 cites W2056255920 @default.
- W1040590940 cites W2058178695 @default.
- W1040590940 cites W2058263296 @default.
- W1040590940 cites W2058527266 @default.
- W1040590940 cites W2059432035 @default.
- W1040590940 cites W2060657236 @default.
- W1040590940 cites W2061579872 @default.
- W1040590940 cites W2070123919 @default.
- W1040590940 cites W2071366986 @default.
- W1040590940 cites W2071988704 @default.
- W1040590940 cites W2075232068 @default.
- W1040590940 cites W2078916174 @default.
- W1040590940 cites W2080479559 @default.
- W1040590940 cites W2082424882 @default.
- W1040590940 cites W2087244246 @default.
- W1040590940 cites W2087485426 @default.
- W1040590940 cites W2087608761 @default.
- W1040590940 cites W2088888513 @default.
- W1040590940 cites W2090521420 @default.
- W1040590940 cites W2091106276 @default.
- W1040590940 cites W2091277893 @default.
- W1040590940 cites W2092510918 @default.
- W1040590940 cites W2094071858 @default.
- W1040590940 cites W2094289966 @default.
- W1040590940 cites W2097154583 @default.
- W1040590940 cites W2098006500 @default.
- W1040590940 cites W2098597269 @default.
- W1040590940 cites W2100569300 @default.
- W1040590940 cites W2101674837 @default.
- W1040590940 cites W2102821130 @default.
- W1040590940 cites W2106590113 @default.
- W1040590940 cites W2109027145 @default.
- W1040590940 cites W2109572873 @default.
- W1040590940 cites W2109793735 @default.
- W1040590940 cites W2111516721 @default.
- W1040590940 cites W2111703131 @default.
- W1040590940 cites W2112314135 @default.
- W1040590940 cites W2112576552 @default.
- W1040590940 cites W2112967578 @default.
- W1040590940 cites W2113191705 @default.
- W1040590940 cites W2113957516 @default.
- W1040590940 cites W2114686855 @default.
- W1040590940 cites W2116193600 @default.
- W1040590940 cites W2116230114 @default.
- W1040590940 cites W2118857271 @default.
- W1040590940 cites W2120704894 @default.
- W1040590940 cites W2120840312 @default.
- W1040590940 cites W2121356953 @default.
- W1040590940 cites W2122470547 @default.