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• W1040654690 abstract "Publisher Summary This chapter discusses the recent advances in gamete biology and their possible applications to fertility control. The gamete biology is divided in five categories: sperm capacitation, sperm enzymes, sexing of spermatozoa, surface interactions among gametes, and immunization against egg components. Capacitation, the process by which the inseminated spermatozoon acquires the ability to fertilize the ovum, has been proposed as an attractive target for fertility control. Studies with specific enzyme inhibitors showed that the capacitation of hamster spermatozoa in vitro by the cumulus oophorus requires action by the glycosidases, β-glucuronidase and β-N-acetylglucosaminidase. However, these enzymes are not unique to the cumulus cells and so it seems doubtful that inhibitors will block capacitation in vivo without side effects. Acrosin is trypsin-like in its substrate specificity; attempts have been made to inhibit fertilization using the trypsin inhibitors, Nα-tosyl-L-lysyl chloromethane, and soybean trypsin inhibitor. In the sexing of spermatozoa by two distinctly different approaches are used Bennett and Boyse approach and the second approach relies for assay on the fact that human Y sperm can be distinguished from X sperm by the presence of a bright fluorescent spot—the so-called “F-body.” Gamete biology is uncovering a series of novel reproductive processes of possible application to fertility control." @default.
• W1040654690 created "2016-06-24" @default.
• W1040654690 creator A5010816190 @default.
• W1040654690 date "1975-01-01" @default.
• W1040654690 modified "2023-09-28" @default.
• W1040654690 title "Chapter 24. Recent Advances in Gamete Biology and Their Possible Application to Fertility Control" @default.
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• W1040654690 doi "https://doi.org/10.1016/s0065-7743(08)61012-x" @default.
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