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- W1040809817 abstract "Publisher Summary This chapter discusses the clinical pharmacokinetics of acetylcholinesterase inhibitors. Clinical pharmacokinetics is the study of absorption, distribution, and elimination of drugs in patients. Clinical pharmacokinetics also includes studies on the relationship between any clinical effect and the measured plasma concentrations of the drug. The development of selective and sensitive analytical methods for the assay of biological samples of acetylcholineesterase inhibitors is an important step forward toward understanding their pharmacokinetic properties, and hence their mode of action and the interindividual variation of clinical response provide a guide for dosage strategies aimed at optimal effect without side effects. The chapter surveys the clinical pharmacokinetic information available on the reversible acetylcholinesterase inhibitors and particularly results emanating from the studies. Analysis of acetylcholinesterase inhibitors in biological samples presents a particular challenge to the analytical chemist, because the plasma concentrations of these drugs are usually in the low ng/ml range. Early methods of analysis based on paper chromatography, spectrometry, and radioisotope studies suffer from poor sensitivity and selectivity regarding the accurate measurement of plasma concentrations following therapeutic doses." @default.
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- W1040809817 date "1990-01-01" @default.
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- W1040809817 title "Chapter 15 Clinical pharmacokinetics of acetylcholinesterase inhibitors" @default.
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- W1040809817 doi "https://doi.org/10.1016/s0079-6123(08)60897-3" @default.
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