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- W1040888859 endingPage "431" @default.
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- W1040888859 abstract "This chapter discusses the mechanism of nucleophilic aromatic substitution reactions. The knowledge of mechanism is most sophisticated for the SN2 nucleophilic displacements, where the reactive agent is an electron donor, where the leaving group is a halogen ion or some other group capable of some stability as an anion, and where the activation is due to electron-withdrawing substituents, suitably positioned in the aromatic substrate. The most widely accepted mechanism for this category of reactions is one involving an intermediate complex, formed by the addition of the nucleophile to the carbon atom undergoing substitution and converting that carbon atom to one with its substituents arranged in a tetrahedral configuration. The best evidence for this interpretation comes from the studies of reaction rates and, in particular, from the observation of the effects of basic catalysts on the rates of reactions with selected substrates and selected nucleophiles. A treatise on kinetics is a logical and fitting medium in which the limitations and uncertainties of the mechanism are analyzed and discussed. The chapter focuses on such a treatment for the SN2 mechanism in nucleophilic aromatic substitution." @default.
- W1040888859 created "2016-06-24" @default.
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- W1040888859 date "1972-01-01" @default.
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- W1040888859 title "Chapter 2 Nucleophilic Aromatic Substitution: the SN2 Mechanism" @default.
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- W1040888859 doi "https://doi.org/10.1016/s0069-8040(08)70135-3" @default.
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