FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1041469306> ?p ?o ?g. }

• W1041469306 endingPage "23" @default.
• W1041469306 startingPage "1" @default.
• W1041469306 abstract "Called by many as the biology's version of Swiss army knives, proteases cut long sequences of amino acids into fragments and regulate most physiological processes. They are vitally important in life cycle and have become a main target for drug design. This Chapter is focused on a special protease that plays a key role in replicating SARS (Severe Acute Respiratory Syndrome) coronavirus, the culprit of SARS disease. The progresses reported here are mainly from various computational approaches, such as structural bioinformatics, pharmacophore modelling, molecular docking, and peptide-cleavage site prediction, among others. It is highlighted that the compounds C28H34O4N7Cl, C21H36O5N6 and C21H36O5N6, as well as KZ7088, a derivative of AG7088, might be the promising candidates for further investigation, and that the octapeptides ATLQAIAS and ATLQAENV, as well as AVLQSGFR, might be converted to effective inhibitors against the SARS protease. Meanwhile, how to modify these octapeptides based on the “distorted key” theory to make them become potent inhibitors is explicitly elucidated. Also, a brief introduction is given for how to use computer-generated graphs to rapidly diagnose SARS coronavirus. Finally, a step-by-step protocol guide is given on how to use ProtIdent, a web-server developed recently, to identify the proteases and their types based on their sequence information alone. ProtIdent is a very user-friendly bioin-formatics tool that can provide desired information for both basic research and drug discovery in a timely manner. With the avalanche of protein sequences generated in the post-genomic age, it is particularly useful. ProtIdent is freely accessible to the public via the web-site at http://www.csbio.sjtu.edu.cn/bioinf/Protease/ ." @default.
• W1041469306 created "2016-06-24" @default.
• W1041469306 creator A5009739089 @default.
• W1041469306 creator A5031196253 @default.
• W1041469306 creator A5041491902 @default.
• W1041469306 creator A5042932209 @default.
• W1041469306 creator A5056115552 @default.
• W1041469306 creator A5076024045 @default.
• W1041469306 date "2009-01-01" @default.
• W1041469306 modified "2023-10-01" @default.
• W1041469306 title "Study of Inhibitors Against SARS Coronavirus by Computational Approaches" @default.
• W1041469306 cites W1514209943 @default.
• W1041469306 cites W1561712938 @default.
• W1041469306 cites W1574994167 @default.
• W1041469306 cites W1964600660 @default.
• W1041469306 cites W1969021871 @default.
• W1041469306 cites W1971603507 @default.
• W1041469306 cites W1973203942 @default.
• W1041469306 cites W1978385569 @default.
• W1041469306 cites W1979154934 @default.
• W1041469306 cites W1980577470 @default.
• W1041469306 cites W1981532526 @default.
• W1041469306 cites W1982276763 @default.
• W1041469306 cites W1985469117 @default.
• W1041469306 cites W1987713050 @default.
• W1041469306 cites W1990376815 @default.
• W1041469306 cites W2004672437 @default.
• W1041469306 cites W2006024094 @default.
• W1041469306 cites W2006641674 @default.
• W1041469306 cites W2013114984 @default.
• W1041469306 cites W2013970374 @default.
• W1041469306 cites W2014762261 @default.
• W1041469306 cites W2015692100 @default.
• W1041469306 cites W2015794241 @default.
• W1041469306 cites W2015827812 @default.
• W1041469306 cites W2016376459 @default.
• W1041469306 cites W2019625760 @default.
• W1041469306 cites W2027484375 @default.
• W1041469306 cites W2032204743 @default.
• W1041469306 cites W2037669417 @default.
• W1041469306 cites W2037831301 @default.
• W1041469306 cites W2040794745 @default.
• W1041469306 cites W2045393117 @default.
• W1041469306 cites W2056180063 @default.
• W1041469306 cites W2057204902 @default.
• W1041469306 cites W2057222141 @default.
• W1041469306 cites W2057713403 @default.
• W1041469306 cites W2064885619 @default.
• W1041469306 cites W2069506489 @default.
• W1041469306 cites W2074995652 @default.
• W1041469306 cites W2075047808 @default.
• W1041469306 cites W2077538414 @default.
• W1041469306 cites W2078436697 @default.
• W1041469306 cites W2078906786 @default.
• W1041469306 cites W2083139287 @default.
• W1041469306 cites W2084387914 @default.
• W1041469306 cites W2087876594 @default.
• W1041469306 cites W2089829590 @default.
• W1041469306 cites W2090196107 @default.
• W1041469306 cites W2093120270 @default.
• W1041469306 cites W2095424887 @default.
• W1041469306 cites W2095635653 @default.
• W1041469306 cites W2098556826 @default.
• W1041469306 cites W2099383692 @default.
• W1041469306 cites W2100145668 @default.
• W1041469306 cites W2103881408 @default.
• W1041469306 cites W2107350531 @default.
• W1041469306 cites W2110896564 @default.
• W1041469306 cites W2111663143 @default.
• W1041469306 cites W2113431950 @default.
• W1041469306 cites W2113590605 @default.
• W1041469306 cites W2116420909 @default.
• W1041469306 cites W2119146932 @default.
• W1041469306 cites W2128468782 @default.
• W1041469306 cites W2129542667 @default.
• W1041469306 cites W2140445305 @default.
• W1041469306 cites W2141853895 @default.
• W1041469306 cites W2142941502 @default.
• W1041469306 cites W2143885473 @default.
• W1041469306 cites W2143992167 @default.
• W1041469306 cites W2153322370 @default.
• W1041469306 cites W2156081660 @default.
• W1041469306 cites W2158812536 @default.
• W1041469306 cites W2169567999 @default.
• W1041469306 cites W2170171492 @default.
• W1041469306 cites W2335537777 @default.
• W1041469306 doi "https://doi.org/10.1007/978-90-481-2348-3_1" @default.
• W1041469306 hasPublicationYear "2009" @default.
• W1041469306 type Work @default.
• W1041469306 sameAs 1041469306 @default.
• W1041469306 citedByCount "3" @default.
• W1041469306 countsByYear W10414693062020 @default.
• W1041469306 countsByYear W10414693062021 @default.
• W1041469306 crossrefType "book-chapter" @default.
• W1041469306 hasAuthorship W1041469306A5009739089 @default.
• W1041469306 hasAuthorship W1041469306A5031196253 @default.
• W1041469306 hasAuthorship W1041469306A5041491902 @default.
• W1041469306 hasAuthorship W1041469306A5042932209 @default.

• next