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• W1041490 endingPage "212" @default.
• W1041490 startingPage "177" @default.
• W1041490 abstract "Preclinical development of scyllo-inositol for the treatment of Alzheimer’s disease (AD) has been investigated in both in vitro and in vivo models with positive results. scyllo-Inositol stabilized a small conformer of Aβ42 in vitro, neutralized cell derived Aβ trimers and promoted low molecular weight Aβ species in vivo. These interactions resulted in decreased neuronal toxicity, increased long-term potentiation (LTP) and ablation of cognitive deficits in multiple mouse models of AD. scyllo-Inositol bioavailability, pharmacokinetics, and small animal toxicology studies demonstrated the potential for translation to human patients. The results of Phase I and Phase II clinical trials for AD are presented. Furthermore, the use of this compound for imaging and other amyloid related disorders is discussed." @default.
• W1041490 created "2016-06-24" @default.
• W1041490 creator A5014013622 @default.
• W1041490 creator A5021078664 @default.
• W1041490 creator A5088635351 @default.
• W1041490 date "2012-01-01" @default.
• W1041490 modified "2023-10-15" @default.
• W1041490 title "scyllo-Inositol, Preclinical, and Clinical Data for Alzheimer’s Disease" @default.
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